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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nle1
notchless homolog 1
MGI:2429770
23 phenotypes from 6 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nle1l11Jus1/Nle1l11Jus1
Not Specified 		absent egg cylinders J:109155
embryonic lethality between implantation and somite formation, complete penetrance J:109155
Nle1l11Jus4/Nle1l11Jus4
Not Specified 		embryonic lethality between implantation and somite formation, complete penetrance J:109155
Nle1rs13468707-C/Nle1rs13468707-C
C57BL/6J 		embryonic lethality between implantation and somite formation, complete penetrance J:193532
Nle1tm1.2Cota/Nle1tm1.2Cota
involves: 129S2/SvPas 		abnormal embryo development J:204063
failure of blastocyst to hatch from the zona pellucida J:204063
Nle1tm1Cba/Nle1tm1.1Cota
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S2/SvPas 		normal hematopoietic system phenotype J:204063
normal immune system phenotype J:204063
Nle1tm1Cba/Nle1tm1.1Cota
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal bone marrow cell morphology/development J:204063
abnormal common lymphocyte progenitor cell morphology J:204063
abnormal hematopoietic stem cell physiology J:204063
abnormal immune system organ morphology J:204063
abnormal intestinal epithelium morphology J:204063
abnormal ribosome biogenesis J:204063
decreased bone marrow cell number J:204063
decreased common myeloid progenitor cell number J:204063
decreased granulocyte number J:204063
decreased macrophage cell number J:204063
decreased NK cell number J:204063
decreased T cell number J:204063
normal hematopoietic system phenotype J:204063
impaired hematopoiesis J:204063
premature death J:204063
spleen hypoplasia J:204063
thymus hypoplasia J:204063
Nle1tm1Cba/Nle1tm1Cba
involves: 129S2/SvPas * C57BL/6 * SJL/J 		abnormal inner cell mass apoptosis J:108385
embryonic lethality between implantation and somite formation, complete penetrance J:108385
failure of blastocyst to hatch from the zona pellucida J:108385
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory