Sctr Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sctr
secretin receptor
MGI:2441720

30 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sctr^tm1Bkcc/Sctr^tm1Bkcc B6.129S7-Sctr^tm1Bkcc	abnormal circulating antidiuretic hormone level	J:166370
	abnormal cytokine secretion	J:121376
	abnormal drinking behavior	J:166370
	abnormal kidney cortex morphology	J:121376
	abnormal kidney medulla morphology	J:121376
	abnormal response/metabolism to endogenous compounds	J:166370
	decreased urine creatinine level	J:121376
	decreased urine osmolality	J:121376
	decreased urine potassium level	J:121376
	decreased urine sodium level	J:121376
	decreased urine urea nitrogen level	J:121376
	dilated kidney collecting duct	J:121376
	expanded mesangial matrix	J:121376
	glomerulosclerosis	J:121376
	increased circulating glucose level	J:121376
	increased glomerular capsule space	J:121376
	increased macrophage cell number	J:121376
	kidney inflammation	J:121376
	polydipsia	J:121376
	polyuria	J:121376
Sctr^tm1Brd/Sctr^tm1Brd involves: 129S7/SvEvBrd * C57BL/6J	abnormal CNS synaptic transmission	J:114853
	abnormal dendritic spine morphology	J:114853
	abnormal excitatory postsynaptic potential	J:114853
	abnormal hippocampal pyramidal neuron dendrite morphology	J:114853
	abnormal social recognition	J:114853
	abnormal social/conspecific interaction behavior	J:114853
	impaired coordination	J:114853
	impaired spatial learning	J:114853
	increased locomotor activity	J:114853
	reduced long-term potentiation	J:114853

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24