Gak Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gak
cyclin G associated kinase
MGI:2442153

45 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gak^{em1(IMPC)Ccpcz}/Gak⁺ C57BL/6NCrl-Gak^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal mammary gland morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	decreased mean corpuscular hemoglobin	J:211773
	decreased mean corpuscular volume	J:211773
	enlarged heart	J:211773
	enlarged kidney	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	increased circulating potassium level	J:211773
	increased kidney weight	J:211773
	increased red blood cell distribution width	J:211773
Gak^{em1(IMPC)Ccpcz}/Gak^{em1(IMPC)Ccpcz} C57BL/6NCrl-Gak^{em1(IMPC)Ccpcz}/Ccpcz	preweaning lethality, complete penetrance	J:211773
Gak^tm1Legr/Gak^tm1Legr involves: 129S6/SvEvTac * C57BL/6	embryonic lethality, complete penetrance	J:180119
Gak^tm1Noj/Gak^tm1Noj C57BL/6-Gak^tm1Noj	abnormal lung alveolus development	J:179585
	abnormal pulmonary alveolar sac morphology	J:179585
	abnormal pulmonary interalveolar septum morphology	J:179585
	abnormal surfactant physiology	J:179585
	normal cellular phenotype	J:179585
	neonatal lethality, complete penetrance	J:179585
Gak^tm2Legr/Gak^tm2Legr involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:180119
Gak^tm2Legr/Gak^tm2Legr involves: 129S6/SvEvTac * C57BL/6	abnormal plasma membrane morphology	J:180119
Gak^tm2Legr/Gak^tm2Legr Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * DBA	abnormal bile duct morphology	J:180119
	abnormal hepatoblast differentiation	J:180119
	abnormal liver morphology	J:180119
	decreased body size	J:180119
	decreased liver glycogen level	J:180119
	increased body weight	J:180119
	jaundice	J:180119
	postnatal lethality, complete penetrance	J:180119
Gak^tm2Legr/Gak^tm2Legr Tg(CAG-cre/Esr1)5Amc/0 involves: 129S6/SvEvTac C57BL/6 * CBA	premature death	J:180119
Gak^tm2Legr/Gak^tm2Legr Tg(KRT14-cre)1Amc/0 involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal epidermal layer morphology	J:180119
	abnormal epidermis stratum corneum morphology	J:180119
	dehydration	J:180119
	impaired skin barrier function	J:180119
	postnatal lethality, complete penetrance	J:180119
	wrinkled skin	J:180119
Gak^tm2Legr/Gak^tm2Legr Tg(Nes-cre)1Kln/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	abnormal Ammon gyrus morphology	J:180119
	abnormal cortical ventricular zone morphology	J:180119
	abnormal dentate gyrus morphology	J:180119
	abnormal neuron differentiation	J:180119
	abnormal neuronal precursor proliferation	J:180119
	decreased neuronal precursor cell number	J:180119
	lethargy	J:180119
	postnatal lethality, complete penetrance	J:180119

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24