Dusp4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dusp4
dual specificity phosphatase 4
MGI:2442191

25 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dusp4^Gt(XG164)Byg/Dusp4^Gt(XG164)Byg B6.129P2-Dusp4^Gt(XG164)Byg	normal immune system phenotype	J:180366
	increased CD4-positive, alpha-beta T cell number	J:180366
	increased interleukin-10 secretion	J:180366
	increased T cell proliferation	J:180366
Dusp4^{tm1a(EUCOMM)Wtsi}/Dusp4^{tm1a(EUCOMM)Wtsi} C57BL/6N-Dusp4^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased caudal vertebrae number	J:175295
	decreased circulating glucose level	J:175295
	decreased circulating potassium level	J:175295
	decreased circulating sodium level	J:175295
	decreased lumbar vertebrae number	J:175295
	decreased rib number	J:175295
	decreased thoracic vertebrae number	J:175295
	increased circulating sodium level	J:175295
	increased sacral vertebrae number	J:175295
Dusp4^tm1Jmol/Dusp4^tm1Jmol involves: 129	decreased B cell apoptosis	J:140567
Dusp4^tm1Plev/Dusp4^tm1Plev involves: 129/Sv * C57BL/6	abnormal macrophage physiology	J:170774
	decreased IgG2a level	J:170774
	decreased interferon-gamma secretion	J:170774
	decreased interleukin-10 secretion	J:170774
	increased IgG1 level	J:170774
	increased interleukin-4 secretion	J:170774
	increased interleukin-6 secretion	J:170774
	increased interleukin-12 secretion	J:170774
	increased interleukin-13 secretion	J:170774
	increased susceptibility to parasitic infection	J:170774
	increased tumor necrosis factor secretion	J:170774

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24