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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plekha1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
MGI:2442213
25 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdgfratm1Sor/Pdgfra+
Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		abnormal ovary morphology J:142042
abnormal vascular smooth muscle morphology J:142042
absent corpus luteum J:142042
anovulation J:142042
decreased circulating estradiol level J:142042
decreased tertiary ovarian follicle number J:142042
decreased theca cell number J:142042
female infertility J:142042
male infertility J:142042
small ovary J:142042
uterus hypoplasia J:142042
Pdgfratm2Sor/Pdgfra+
Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
involves: 129S4/SvJaeSor 		abnormal frontal bone morphology J:117491
abnormal skeleton morphology J:117491
broad snout J:117491
cleft palate J:117491
complete cleft palate J:117491
midline facial cleft J:117491
short maxilla J:117491
short nasal bone J:117491
short premaxilla J:117491
short snout J:117491
Pdgfrbtm1Sor/Pdgfrb+
Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6) 		male infertility J:142042
Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
TiparpGt(ROSA)79Sor/Tiparp+
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) 		normal reproductive system phenotype J:142042
Plekha1tm1.1Arte/Plekha1tm1.1Arte
Plekha2tm1.1Arte/Plekha2tm1.1Arte
C57BL/6J-Plekha1tm1.1Arte Plekha2tm1.1Arte 		increased cardiac muscle cell glucose uptake J:169475
increased insulin sensitivity J:169475
increased skeletal muscle cell glucose uptake J:169475
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory