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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mfn2
mitofusin 2
MGI:2442230
85 phenotypes from 9 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
En1tm2(cre)Wrst/En1+
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129 * 129S4/SvJaeSor * Black Swiss 		abnormal neuron mitochondrial morphology J:132329
abnormal Purkinje cell dendrite morphology J:132329
decreased body size J:132329
impaired limb coordination J:132329
impaired righting response J:132329
increased neuron apoptosis J:132329
postnatal lethality, complete penetrance J:132329
Purkinje cell degeneration J:132329
small cerebellum J:132329
Gabra6tm2(cre)Wwis/Gabra6+
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129 * 129S4/SvJaeSor * Black Swiss 		no abnormal phenotype detected J:132329
Meox2tm1(cre)Sor/Meox2+
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129S/SvEv * 129S4/SvJaeSor * Black Swiss 		decreased body size J:132329
impaired limb coordination J:132329
impaired righting response J:132329
neonatal lethality, incomplete penetrance J:132329
postnatal lethality, complete penetrance J:132329
small cerebellum J:132329
Mfn2em1Cya/Mfn2em1Cya
Tg(Stra8-icre)1Reb/0
involves: C57BL/6J * FVB/NJ 		abnormal male meiosis J:324164
abnormal sperm mitochondrial sheath morphology J:324164
abnormal sperm nucleus morphology J:324164
kinked sperm flagellum J:324164
small seminiferous tubules J:324164
small testis J:324164
Mfn2tm1.1Arte/Mfn2tm1.1Arte
Slc6a3tm1(cre)Lrsn/Slc6a3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal innervation J:188337
abnormal locomotor activation J:188337
abnormal neuron physiology J:188337
abnormal respiratory electron transport chain J:188337
abnormal substantia nigra pars compacta morphology J:188337
decreased body weight J:188337
decreased dopamine level J:188337
decreased locomotor activity J:188337
decreased vertical activity J:188337
increased serotonin level J:188337
premature death J:188337
weight loss J:188337
Mfn2tm1.1Balo/Mfn2tm1.1Balo
Not Specified 		abnormal axonal transport J:159219
abnormal mitochondrial physiology J:159219
lethality throughout fetal growth and development, complete penetrance J:159219
Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal mitochondrial morphology J:188865
Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		abnormal autophagy J:188865
abnormal cellular respiration J:188865
abnormal mitochondrial morphology J:188865
abnormal myocardial fiber morphology J:188865
abnormal myocardial fiber physiology J:188865
decreased heart ventricle muscle contractility J:188865
increased fetal cardiomyocyte apoptosis J:188865
increased response of heart to induced stress J:188865
lipofuscinosis J:188865
Mfn2tm1b(EUCOMM)Wtsi/Mfn2+
C57BL/6N-Mfn2tm1b(EUCOMM)Wtsi/Ieg 		abnormal gait J:211773
decreased lean body mass J:211773
Mfn2tm1b(EUCOMM)Wtsi/Mfn2tm1b(EUCOMM)Wtsi
C57BL/6N-Mfn2tm1b(EUCOMM)Wtsi/Ieg 		preweaning lethality, complete penetrance J:211773
Mfn2tm1Dcc/Mfn2tm1Dcc
involves: 129S/SvEv 		abnormal mitochondrial morphology J:81438
abnormal mitochondrial physiology J:81438
abnormal trophoblast layer morphology J:81438
decreased embryo size J:81438
decreased trophoblast giant cell number J:81438
embryonic lethality during organogenesis, incomplete penetrance J:81438
Mfn2tm1Dcc/Mfn2tm3Dcc
involves: 129 * 129S4/SvJaeSor * Black Swiss 		abnormal mitochondrial morphology J:132329
Mfn2tm1Dcc/Mfn2tm3Dcc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129 * 129S4/SvJaeSor * Black Swiss 		decreased body size J:132329
impaired limb coordination J:132329
impaired righting response J:132329
postnatal lethality, complete penetrance J:132329
small cerebellum J:132329
Mfn2tm1Dcc/Mfn2tm3Dcc
Tg(EIIa-cre)C5379Lmgd/0
involves: 129 * 129S4/SvJaeSor * Black Swiss * FVB/N 		prenatal lethality, complete penetrance J:132329
Mfn2tm1Dcc/Mfn2tm3Dcc
Tg(Pcp2-cre)2Mpin/0
involves: 129 * 129S4/SvJaeSor * Black Swiss 		abnormal cerebellum morphology J:132329
abnormal gait J:132329
abnormal Purkinje cell dendrite morphology J:132329
abnormal Purkinje cell focal axonal swelling J:132329
abnormal Purkinje cell mitochondrial morphology J:132329
abnormal respiratory electron transport chain J:132329
impaired coordination J:132329
Purkinje cell degeneration J:132329
small cerebellum J:132329
Mfn2tm2Dcc/Mfn2tm2Dcc
involves: 129S/SvEv 		abnormal axonal transport J:159219
abnormal mitochondrial physiology J:159219
Mfn2tm2Dcc/Mfn2tm2Dcc
involves: 129S/SvEv * FVB/N 		abnormal mitochondrial morphology J:119702
Mfn2tm3Dcc/Mfn2tm3Dcc
Tg(Stra8-icre)1Reb/0
involves: 129 * C57BL/6J * FVB/NJ 		abnormal endoplasmic reticulum morphology J:305430
abnormal male germ cell morphology J:305430
abnormal male germ cell physiology J:305430
abnormal mitochondrial ATP synthesis coupled electron transport J:305430
abnormal mitochondrial morphology J:305430
abnormal sperm head morphology J:305430
abnormal spermatid morphology J:305430
abnormal spermatocyte morphology J:305430
abnormal spermatogenesis J:305430
absent sperm head J:305430
normal cellular phenotype J:305430
coiled sperm flagellum J:305430
decreased male germ cell number J:305430
decreased testis weight J:305430
increased male germ cell apoptosis J:305430
increased mitochondrial DNA content J:305430
increased mitochondrial fission J:305430
increased testis apoptosis J:305430
male infertility J:305430
oligozoospermia J:305430
seminiferous tubule degeneration J:305430
small epididymis J:305430
small seminiferous tubules J:305430
small testis J:305430
teratozoospermia J:305430
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/0
Not Specified 		abnormal mitochondrial morphology J:132035
kinked tail J:132035
normal limbs/digits/tail phenotype J:132035
short tail J:132035
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
Not Specified 		abnormal autopod morphology J:132035
abnormal gait J:132035
abnormal hindlimb morphology J:132035
abnormal limb posture J:132035
abnormal mitochondrial morphology J:132035
abnormal motor neuron morphology J:132035
abnormal tail morphology J:132035
decreased body weight J:132035
decreased skeletal muscle size J:132035
muscle weakness J:132035
short tail J:132035
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory