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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp4
low density lipoprotein receptor-related protein 4
MGI:2442252
75 phenotypes from 10 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lrp4dan/Lrp4dan
129S2/SvPas-Lrp4dan 		abnormal coat appearance J:108168
abnormal nursing J:108168
brachydactyly J:108168
normal craniofacial phenotype J:108168
decreased body size J:108168
deformed nails J:108168
hunched posture J:108168
polydactyly J:108168
polysyndactyly J:108168
syndactyly J:108168
Lrp4mdig-2J/Lrp4mdig-2J
involves: C3H/HeSnJ * SB/LeJ 		abnormal tail morphology J:165544
oligodactyly J:165544
supernumerary incisors J:165544
Lrp4mdig-3J/Lrp4mdig-3J
B6.Cg-Lrp4mdig-3J/GrsrJ 		abnormal digit morphology J:224655
abnormal spine curvature J:224655
abnormal tooth morphology J:224655
brachydactyly J:224655
decreased body size J:224655
fused phalanges J:224655
reduced fertility J:224655
Lrp4mdig/Lrp4mdig
DBA/1LacJ-Lrp4mdig/GrsrJ 		brachydactyly J:83757
syndactyly J:83757
Lrp4mdig/Lrp4mdig
involves: 129S2/SvPas * DBA/1LacJ 		abnormal nursing J:108168
brachydactyly J:108168
normal craniofacial phenotype J:108168
deformed nails J:108168
polydactyly J:108168
polysyndactyly J:108168
syndactyly J:108168
Lrp4mitt/Lrp4mitt
involves: C57BL/6 		abnormal apical ectodermal ridge morphology J:119654
abnormal digit morphology J:119654
abnormal hair follicle development J:119654
abnormal mammary gland bud morphology J:119654
abnormal motor neuron morphology J:188352
abnormal neuromuscular synapse morphology J:119654
abnormal phrenic nerve morphology J:119654
abnormal tooth development J:119654
abnormal vibrissa morphology J:119654
absent kidney J:119654
atelectasis J:119654
brachypodia J:119654
cyanosis J:119654
ectopic digits J:119654
failure of neuromuscular synapse postsynaptic differentiation J:119654
failure of neuromuscular synapse presynaptic differentiation J:119654
fused metacarpal bones J:119654
fused metatarsal bones J:119654
neonatal lethality, complete penetrance J:119654
no spontaneous movement J:119654
oligodactyly J:119654
respiratory failure J:119654
single kidney J:119654
small lung J:119654
syndactyly J:119654
Lrp4mte/Lrp4mte
involves: C57BL/6 		abnormal apical ectodermal ridge morphology J:119654
abnormal digit morphology J:119654
abnormal hair follicle development J:119654
abnormal mammary gland bud morphology J:119654
abnormal neuromuscular synapse morphology J:119654
abnormal phrenic nerve morphology J:119654
abnormal tooth development J:119654
abnormal vibrissa morphology J:119654
absent kidney J:119654
atelectasis J:119654
brachypodia J:119654
cyanosis J:119654
ectopic digits J:119654
failure of neuromuscular synapse postsynaptic differentiation J:119654
failure of neuromuscular synapse presynaptic differentiation J:119654
fused metacarpal bones J:119654
fused metatarsal bones J:119654
neonatal lethality, complete penetrance J:119654
no spontaneous movement J:119654
oligodactyly J:119654
respiratory failure J:119654
single kidney J:119654
small lung J:119654
syndactyly J:119654
Lrp4tm1.1Line/Lrp4tm1.1Line
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * SJL 		normal nervous system phenotype J:188352
Lrp4tm1.1Line/Lrp4tm1.1Line
Mnx1tm4(cre)Tmj/Mnx1+
Tg(ACTA1-cre)79Jme/0
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL 		abnormal motor neuron morphology J:188352
abnormal neuromuscular synapse morphology J:188352
cyanosis J:188352
neonatal lethality, complete penetrance J:188352
Lrp4tm1.1Line/Lrp4tm1.1Line
Tg(ACTA1-cre)79Jme/0
involves: 129S/SvEv * C57BL/6 * C57BL/6J * SJL 		abnormal endplate potential J:188352
abnormal miniature endplate potential J:188352
abnormal motor neuron morphology J:188352
abnormal neuromuscular synapse morphology J:188352
postnatal lethality, incomplete penetrance J:188352
Lrp4tm1.1Pg/Lrp4+
involves: C57BL/6N 		increased bone strength J:277372
Lrp4tm1.1Pg/Lrp4tm1.1Pg
involves: C57BL/6N 		abnormal blood homeostasis J:277372
abnormal osteocyte morphology J:277372
decreased bone trabecular spacing J:277372
increased bone ossification J:277372
increased bone strength J:277372
increased bone trabecula number J:277372
increased diameter of femur J:277372
increased femur compact bone thickness J:277372
increased trabecular bone connectivity density J:277372
increased trabecular bone thickness J:277372
increased trabecular bone volume J:277372
normal muscle phenotype J:277372
normal renal/urinary system phenotype J:277372
normal skeleton phenotype J:277372
thick neurocranium J:277372
Lrp4tm1Her/Lrp4tm1Her
involves: 129S6/SvEvTac 		abnormal enamel morphology J:156471
abnormal incisor morphology J:156471
supernumerary incisors J:156471
Lrp4tm1Her/Lrp4tm1Her
involves: 129S6/SvEvTac * C57BL/6 		abnormal chondrocyte morphology J:106811
abnormal digit morphology J:106811
abnormal forelimb morphology J:106811
abnormal hindlimb morphology J:106811
abnormal incisor morphology J:106811
abnormal postnatal growth J:106811
polydactyly J:106811
preweaning lethality, incomplete penetrance J:106811
thick apical ectodermal ridge J:106811
Lrp4tm1Her/Lrp4tm1Her
involves: 129S/SvEvBrd * 129S6/SvEvTac * C57BL/6J 		abnormal neuromuscular synapse morphology J:207796
Lrp4tm2Her/Lrp4tm2Her
involves: 129S/SvEv 		abnormal incisor morphology J:156471
abnormal molar cusp morphology J:156471
supernumerary incisors J:156471
Lrp4tm2Her/Lrp4tm2Her
involves: 129S/SvEv * C57BL 		abnormal kidney development J:160547
abnormal neuromuscular synapse morphology J:160547
abnormal ureteric bud invasion J:160547
abnormal ureteric bud morphology J:160547
absent kidney J:160547
absent metanephric mesenchyme J:160547
impaired branching involved in ureteric bud morphogenesis J:160547
neonatal lethality, complete penetrance J:160547
single kidney J:160547
ureter hypoplasia J:160547
Lrp4tm2Her/Lrp4tm2Her
involves: 129S/SvEvBrd * C57BL/6J 		abnormal neuromuscular synapse morphology J:207796
failure of neuromuscular synapse postsynaptic differentiation J:207796
failure of neuromuscular synapse presynaptic differentiation J:207796
perinatal lethality, complete penetrance J:207796
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory