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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kat6a
K(lysine) acetyltransferase 6A
MGI:2442415
67 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kat6atm1.1Glac/Kat6a+
involves: 129P2/OlaHsd * C57BL/6 		abnormal hematopoietic stem cell morphology J:148955
decreased erythroid progenitor cell number J:148955
decreased hematopoietic stem cell number J:148955
Kat6atm1.1Glac/Kat6atm1.1Glac
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell differentiation J:148955
abnormal hematopoietic stem cell morphology J:148955
decreased body weight J:148955
decreased common myeloid progenitor cell number J:148955
decreased hematopoietic stem cell number J:148955
decreased immature B cell number J:148955
decreased pre-B cell number J:148955
decreased pro-B cell number J:148955
decreased spleen weight J:148955
decreased thymus weight J:148955
premature death J:148955
spleen hypoplasia J:148955
thymus hypoplasia J:148955
Kat6atm1Avo/Kat6a+
either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) 		reduced fertility J:108453
Kat6atm1Avo/Kat6a+
involves: 129 * BALB/c * FVB/N 		abnormal definitive hematopoiesis J:108453
abnormal response/metabolism to endogenous compounds J:188772
cleft secondary palate J:188772
interrupted aortic arch, type b J:188772
normal reproductive system phenotype J:108453
retroesophageal right subclavian artery J:188772
small thymus J:188772
transposition of great arteries J:188772
Kat6atm1Avo/Kat6atm1Avo
either: 129 or (involves: 129 * C57BL/6) or (129 * BALB/c * FVB/N) 		abnormal cervical atlas morphology J:155755
abnormal cervical vertebrae morphology J:155755
abnormal innervation J:155755
decreased thoracic vertebrae number J:155755
hunched posture J:155755
thoracic vertebral transformation J:155755
Kat6atm1Avo/Kat6atm1Avo
involves: 129/Sv * BALB/c * FVB/N 		abnormal aortic arch morphology J:108453, J:188772
abnormal craniofacial morphology J:108453
abnormal erythropoiesis J:108453
abnormal fourth pharyngeal arch artery morphology J:188772
abnormal heart morphology J:188772
abnormal hematopoietic stem cell morphology J:188772
abnormal pulmonary trunk morphology J:188772
abnormal thymus development J:108453
abnormal vertebrae morphology J:188772
absent spleen J:108453
athymia J:188772
atrial septal defect J:188772
atrioventricular septal defect J:188772
cleft palate J:108453, J:188772
common ventricle J:188772
cyanosis J:108453
decreased bone marrow cell number J:108453
decreased double-negative T cell number J:108453
decreased hematopoietic stem cell number J:108453
hemorrhage J:108453
increased nucleated erythrocyte cell number J:108453
interrupted aortic arch, type b J:188772
micrognathia J:188772
neonatal lethality, complete penetrance J:188772
overriding aortic valve J:188772
perinatal lethality, complete penetrance J:108453
retroesophageal right subclavian artery J:188772
small thymus J:108453, J:188772
thymus hypoplasia J:108453
ventricular septal defect J:188772
Kat6atm1b(EUCOMM)Wtsi/Kat6atm1b(EUCOMM)Wtsi
involves: C57BL/6J * C57BL/6N 		abnormal vascular development J:222304
decreased fetal size J:222304
lethality throughout fetal growth and development J:222304
Kat6atm1c(EUCOMM)Wtsi/Kat6atm1c(EUCOMM)Wtsi
Emx1tm1(cre)Krj/Emx1+
involves: 129S2/SvPas * C57BL/6J * C57BL/6N * CD-1 		no abnormal phenotype detected J:224155
Kat6atm1Iki/Kat6atm1Iki
Not Specified 		abnormal erythropoiesis J:108699
abnormal myelopoiesis J:108699
abnormal tail morphology J:108699
absent common myeloid progenitor cells J:108699
decreased B cell number J:108699
decreased hematopoietic stem cell number J:108699
hemorrhage J:108699
lethality throughout fetal growth and development, complete penetrance J:108699
liver hypoplasia J:108699
pallor J:108699
skin edema J:108699
small liver J:108699
Kat6atm2.2Avo/Kat6a+
involves: BALB/c * C57BL/6 * FVB 		abnormal craniofacial morphology J:188772
abnormal heart morphology J:188772
retroesophageal right subclavian artery J:188772
ventricular septal defect J:188772
Kat6atm2.2Avo/Kat6atm2.2Avo
either: (involves: 129 * C57BL/6) or (involves: 129 * BALB/c * FVB/N) 		abnormal chromosome morphology J:155755
Kat6atm2.2Avo/Kat6atm2.2Avo
involves: BALB/c * C57BL/6 * FVB 		abnormal hematopoietic stem cell morphology J:188772
lethality throughout fetal growth and development, complete penetrance J:188772
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory