Arhgef4 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arhgef4
Rho guanine nucleotide exchange factor 4
MGI:2442507

17 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Arhgef4^{tm1a(KOMP)Wtsi}/Arhgef4^{tm1a(KOMP)Wtsi} C57BL/6N-Arhgef4^{tm1a(KOMP)Wtsi}/Wtsi	abnormal response to tactile stimuli	J:165965
	decreased bone mineral density	J:165965
	decreased circulating triglyceride level	J:165965
	decreased hemoglobin content	J:165965
	decreased IgE level	J:165965
	decreased IgG1 level	J:165965
	decreased T cell number	J:165965
	increased circulating alkaline phosphatase level	J:165965
	increased circulating total protein level	J:165965
	increased mature B cell number	J:165965
Arhgef4^tm1Taki/Arhgef4^tm1Taki B6J.Cg-Arhgef4^tm1Taki	no abnormal phenotype detected	J:157023
Arhgef4^tm1Taki/Arhgef4^tm1Taki involves: C57BL/6 * C57BL/6J * CBA	abnormal tumor morphology	J:159959
	abnormal tumor vascularization	J:159959
	abnormal vascular endothelial cell migration	J:159959
	abnormal vascular endothelial cell physiology	J:159959
	decreased angiogenesis	J:159959
	decreased tumor growth/size	J:159959

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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