Stk38 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stk38
serine/threonine kinase 38
MGI:2442572

28 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stk38^em1Flca/Stk38^em1Flca C57BL/6-Stk38^em1Flca	abnormal amacrine cell morphology	J:265036
	abnormal eye physiology	J:265036
	abnormal retina inner nuclear layer thickness	J:265036
	abnormal retina morphology	J:265036
	increased retina apoptosis	J:265036
	thin retina outer nuclear layer	J:265036
	normal vision/eye phenotype	J:265036
Stk38^em2Flca/Stk38^em2Flca C57BL/6-Stk38^em2Flca	abnormal amacrine cell morphology	J:265036
	abnormal eye physiology	J:265036
	abnormal retina inner nuclear layer thickness	J:265036
	abnormal retina morphology	J:265036
	increased retina apoptosis	J:265036
	thin retina outer nuclear layer	J:265036
	normal vision/eye phenotype	J:265036
Stk38^{tm1b(KOMP)Wtsi}/Stk38⁺ C57BL/6N-Stk38^{tm1b(KOMP)Wtsi}/J	abnormal auditory brainstem response	J:211773
	increased fasting circulating glucose level	J:211773
	increased heart weight	J:211773
	increased leukocyte cell number	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
Stk38^{tm1b(KOMP)Wtsi}/Stk38^{tm1b(KOMP)Wtsi} C57BL/6N-Stk38^{tm1b(KOMP)Wtsi}/J	preweaning lethality, incomplete penetrance	J:211773
Stk38^tm1Hem/Stk38⁺ involves: 129P2/Ola * C57BL/6	decreased sensitivity to induced cell death	J:185408
	increased incidence of tumors by chemical induction	J:185408
	increased T cell derived lymphoma incidence	J:185408
Stk38^tm1Hem/Stk38^tm1Hem involves: 129P2/Ola * C57BL/6	abnormal T cell physiology	J:185408
	decreased cellular sensitivity to gamma-irradiation	J:185408
	decreased sensitivity to induced cell death	J:185408
	decreased thymocyte apoptosis	J:185408
	increased incidence of tumors by chemical induction	J:185408
	increased T cell derived lymphoma incidence	J:185408
Stk38^tm1Xen/Stk38^tm1Xen involves: 129S5/SvEvBrd * C57BL/6	normal immune system phenotype	J:224932
	increased circulating interleukin-6 level	J:224932
	increased circulating tumor necrosis factor level	J:224932
	increased interleukin-6 secretion	J:224932
	increased susceptibility to bacterial infection	J:224932
	increased susceptibility to bacterial infection induced morbidity/mortality	J:224932
	increased susceptibility to induced morbidity/mortality	J:224932
	increased susceptibility to injury	J:224932
	increased tumor necrosis factor secretion	J:224932

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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