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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rc3h2
ring finger and CCCH-type zinc finger domains 2
MGI:2442789
20 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rc3h1san/Rc3h1san
Rc3h2tm1.2Cgv/Rc3h2tm1.2Cgv
involves: C57BL/6 * C57BL/6JSfdAnu 		increased circulating tumor necrosis factor level J:196137
increased inflammatory response J:196137
increased susceptibility to bacterial infection J:196137
increased T follicular helper cell number J:196137
kidney inflammation J:196137
premature death J:196137
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi
Tg(Cd4-cre)1Cwi/?
involves: C57BL/6N * DBA/2 		abnormal B cell number J:196136
abnormal immune system cell morphology J:196136
abnormal immune system organ morphology J:196136
abnormal immune system physiology J:196136
abnormal spleen B cell follicle morphology J:196136
abnormal spleen morphology J:196136
abnormal spleen periarteriolar lymphoid sheath morphology J:196136
decreased CD4-positive, alpha-beta T cell number J:196136
decreased CD8-positive, alpha-beta T cell number J:196136
decreased T cell number J:196136
enlarged lymph nodes J:196136
enlarged spleen J:196136
increased germinal center B cell number J:196136
increased T cell proliferation J:196136
increased T follicular helper cell number J:196136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory