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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Brip1
BRCA1 interacting protein C-terminal helicase 1
MGI:2442836
47 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Brip1em1(IMPC)J/Brip1em1(IMPC)J
C57BL/6NJ-Brip1em1(IMPC)J/Mmjax 		abnormal coat/ hair morphology J:211773
abnormal coat/hair pigmentation J:211773
abnormal gait J:211773
abnormal limb position J:211773
cataract J:211773
decreased grip strength J:211773
hyperactivity J:211773
increased circulating alkaline phosphatase level J:211773
increased mean corpuscular volume J:211773
thrombocytopenia J:211773
Brip1Gt(RRI409)Byg/Brip1Gt(RRI409)Byg
involves: 129P2/OlaHsd 		abnormal cell physiology J:227115, J:227337
abnormal chiasmata formation J:227337
abnormal chromosome morphology J:227115
abnormal DNA replication J:227115
abnormal double-strand DNA break repair J:227115, J:227337
abnormal ovary development J:227115
abnormal seminiferous tubule epithelium morphology J:227337
abnormal seminiferous tubule morphology J:227115
abnormal spermatogonia morphology J:227115
abnormal spermatogonia proliferation J:227337
abnormal X-Y chromosome synapsis during male meiosis J:227337
chromosomal instability J:227115
decreased cell proliferation J:227337
decreased litter size J:227115
decreased primary ovarian follicle number J:227115
decreased primordial germ cell number J:227337
decreased primordial germ cell proliferation J:227337
decreased testis weight J:227115, J:227337
early cellular replicative senescence J:227115
endometrium hyperplasia J:227115
hepatic steatosis J:227115
increased adenocarcinoma incidence J:227115
increased adenoma incidence J:227115
increased cellular sensitivity to DNA damaging agents J:227115
increased Harderian gland adenoma incidence J:227115
increased lymphoma incidence J:227115
increased pituitary adenoma incidence J:227115
increased primordial germ cell apoptosis J:227337
increased Sertoli cell number J:227115
increased tumor incidence J:227115
induced chromosome breakage J:227115
oligozoospermia J:227337
ovary cyst J:227115
reduced fertility J:227115
small testis J:227115, J:227337
testicular atrophy J:227115
testis hypoplasia J:227337
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory