Mettl14 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mettl14
methyltransferase 14, N6-adenosine-methyltransferase subunit
MGI:2442926

27 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mettl14^em1(IMPC)Tcp/Mettl14⁺ C57BL/6NCrl-Mettl14^em1(IMPC)Tcp/Tcp	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal uterus morphology	J:211773
	decreased exploration in new environment	J:211773
	small spleen	J:211773
Mettl14^em1(IMPC)Tcp/Mettl14^em1(IMPC)Tcp C57BL/6NCrl-Mettl14^em1(IMPC)Tcp/Tcp	embryonic lethality prior to organogenesis	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Mettl14^em1Chhe/Mettl14^em1Chhe Stra8^{em1(GFP/cre)Smoc}/Stra8⁺ involves: C57BL/6J	abnormal epigenetic regulation of gene expression	J:250428
	normal reproductive system phenotype	J:250428
Mettl14^em1Chhe/Mettl14^em1Chhe Tg(Ddx4-cre)1Dcas/0 involves: C57BL/6J * FVB	abnormal epigenetic regulation of gene expression	J:250428
	abnormal seminiferous tubule epithelium morphology	J:250428
	abnormal spermatogonia morphology	J:250428
	abnormal translation	J:250428
	decreased male germ cell number	J:250428
	male infertility	J:250428
	small testis	J:250428
Mettl14^tm1.1Czhao/Mettl14^tm1.1Czhao Tg(Nes-cre)1Kln/0 involves: 129S6/SvEvTac * C57BL/6NCrl * SJL	abnormal glial cell physiology	J:258043
	decreased neuron number	J:258043
	decreased radial glial cell number	J:258043
	enlarged brain ventricles	J:258043
	postnatal lethality, complete penetrance	J:258043
	thin cerebral cortex	J:258043
Mettl14^tm1.2Czhao/Mettl14^tm1.2Czhao involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N * SJL	abnormal DNA methylation	J:258043
	abnormal neuronal stem cell physiology	J:258043
	embryonic lethality, incomplete penetrance	J:258043
	premature neuronal precursor differentiation	J:258043
	prenatal lethality, complete penetrance	J:258043

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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