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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mettl14
methyltransferase 14, N6-adenosine-methyltransferase subunit
MGI:2442926
27 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mettl14em1(IMPC)Tcp/Mettl14+
C57BL/6NCrl-Mettl14em1(IMPC)Tcp/Tcp 		abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal uterus morphology J:211773
decreased exploration in new environment J:211773
small spleen J:211773
Mettl14em1(IMPC)Tcp/Mettl14em1(IMPC)Tcp
C57BL/6NCrl-Mettl14em1(IMPC)Tcp/Tcp 		embryonic lethality prior to organogenesis J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
Mettl14em1Chhe/Mettl14em1Chhe
Stra8em1(GFP/cre)Smoc/Stra8+
involves: C57BL/6J 		abnormal epigenetic regulation of gene expression J:250428
normal reproductive system phenotype J:250428
Mettl14em1Chhe/Mettl14em1Chhe
Tg(Ddx4-cre)1Dcas/0
involves: C57BL/6J * FVB 		abnormal epigenetic regulation of gene expression J:250428
abnormal seminiferous tubule epithelium morphology J:250428
abnormal spermatogonia morphology J:250428
abnormal translation J:250428
decreased male germ cell number J:250428
male infertility J:250428
small testis J:250428
Mettl14tm1.1Czhao/Mettl14tm1.1Czhao
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6NCrl * SJL 		abnormal glial cell physiology J:258043
decreased neuron number J:258043
decreased radial glial cell number J:258043
enlarged brain ventricles J:258043
postnatal lethality, complete penetrance J:258043
thin cerebral cortex J:258043
Mettl14tm1.2Czhao/Mettl14tm1.2Czhao
involves: 129S6/SvEvTac * C57BL/6NCrl * FVB/N * SJL 		abnormal DNA methylation J:258043
abnormal neuronal stem cell physiology J:258043
embryonic lethality, incomplete penetrance J:258043
premature neuronal precursor differentiation J:258043
prenatal lethality, complete penetrance J:258043
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory