Arfgef1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arfgef1
ARF guanine nucleotide exchange factor 1
MGI:2442988

19 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Arfgef1^{em1(IMPC)Hmgu}/Arfgef1⁺ C57BL/6NCrl-Arfgef1^{em1(IMPC)Hmgu}/Ieg	decreased locomotor activity	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
Arfgef1^{em1(IMPC)Hmgu}/Arfgef1^{em1(IMPC)Hmgu} C57BL/6NCrl-Arfgef1^{em1(IMPC)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Arfgef1^{Gt(CSH465)Byg}/Arfgef1^{Gt(CSH465)Byg} involves: 129P2/OlaHsd * C57BL/6J	abnormal axon extension	J:248338
	abnormal axon guidance	J:248338
	abnormal corpus callosum morphology	J:248338
	abnormal glutaminergic neuron morphology	J:248338
	abnormal neuron differentiation	J:248338
	absent anterior commissure	J:248338
	absent gastric milk in neonates	J:248338
	decreased brain size	J:248338
	decreased neocortex size	J:248338
	delayed axon extension	J:248338
	enlarged lateral ventricles	J:248338
	increased neuron apoptosis	J:248338
	neonatal lethality, complete penetrance	J:248338
	small cerebellum	J:248338
	small hippocampus	J:248338
	thin cerebral cortex	J:248338

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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