About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plekhm1
pleckstrin homology domain containing, family M (with RUN domain) member 1
MGI:2443207
23 phenotypes from 4 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Ctsktm1(cre)Ska/Ctsk+
Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj 		abnormal lysosome morphology J:236517
abnormal osteoclast morphology J:236517
abnormal osteoclast physiology J:236517
decreased bone mineralization J:236517
decreased bone ossification J:236517
decreased bone resorption J:236517
decreased bone trabecular spacing J:236517
decreased lysosomal enzyme secretion J:236517
decreased osteoblast cell number J:236517
increased bone trabecula number J:236517
increased trabecular bone mass J:236517
increased trabecular bone volume J:236517
Plekhm1Gt(OST201689)Lex/Plekhm1Gt(OST201689)Lex
B6;129S5-Plekhm1Gt(OST201689)Lex/Orl 		no abnormal phenotype detected J:82809
Plekhm1tm1.2Hzhao/Plekhm1tm1.2Hzhao
involves: 129S1/Sv * C57BL/6J 		abnormal lysosome morphology J:236517
abnormal osteoclast morphology J:236517
abnormal osteoclast physiology J:236517
decreased bone mineralization J:236517
decreased bone ossification J:236517
decreased bone resorption J:236517
decreased bone trabecular spacing J:236517
decreased lysosomal enzyme secretion J:236517
decreased osteoblast cell number J:236517
increased bone trabecula number J:236517
increased trabecular bone mass J:236517
increased trabecular bone volume J:236517
Plekhm1tm1b(EUCOMM)Hmgu/Plekhm1tm1b(EUCOMM)Hmgu
C57BL/6N-Plekhm1tm1b(EUCOMM)Hmgu/Tcp 		abnormal optic disk morphology J:211773
abnormal vertebrae morphology J:211773
decreased prepulse inhibition J:211773
decreased total body fat amount J:211773
increased bone mineral content J:211773
increased bone mineral density J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
polycystic kidney J:211773
short tibia J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory