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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tet2
tet methylcytosine dioxygenase 2
MGI:2443298
48 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tet2Gt(AN0709)Wtsi/Tet2+
B6.129P2-Tet2Gt(AN0709)Wtsi 		abnormal monocyte differentiation J:174052
abnormal spleen morphology J:174052
anemia J:174052
decreased erythrocyte cell number J:174052
enlarged liver J:174052
enlarged spleen J:174052
increased B cell number J:174052
increased erythroid progenitor cell number J:174052
increased leukocyte cell number J:174052
increased monocyte cell number J:174052
liver fibrosis J:174052
liver inflammation J:174052
premature death J:174052
thrombocytopenia J:174052
weight loss J:174052
Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
B6.129P2-Tet2Gt(AN0709)Wtsi 		abnormal common myeloid progenitor cell morphology J:174052
abnormal monocyte differentiation J:174052
abnormal spleen morphology J:174052
anemia J:174052
decreased erythrocyte cell number J:174052
decreased pre-B cell number J:174052
decreased pro-B cell number J:174052
enlarged liver J:174052
enlarged spleen J:174052
extramedullary hematopoiesis J:174052
increased B cell number J:174052
increased DN1 thymic pro-T cell number J:174052
increased double-negative T cell number J:174052
increased erythroid progenitor cell number J:174052
increased hematopoietic stem cell number J:174052
increased leukocyte cell number J:174052
increased monocyte cell number J:174052
liver inflammation J:174052
premature death J:174052
thrombocytopenia J:174052
weight loss J:174052
Tet2Gt(Ayu17-449)Imeg/Tet2Gt(Ayu17-449)Imeg
involves: C57BL/6 * CBA 		abnormal proximal convoluted tubule morphology J:140275
neonatal lethality, incomplete penetrance J:140275
postnatal lethality J:140275
Tet2tm1.1Iaai/Tet2+
Tg(VAV1-cre)1Graf/0
involves: 129S/SvEv * C57BL/6 		abnormal hematopoietic stem cell physiology J:174053
extramedullary hematopoiesis J:174053
increased hematopoietic cell number J:174053
increased leukocyte cell number J:174053
increased monocyte cell number J:174053
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S/SvEv * C57BL/6 * FVB/N 		no abnormal phenotype detected J:174053
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA 		abnormal erythropoiesis J:234976
abnormal hematopoietic stem cell physiology J:174053
abnormal myelopoiesis J:234976
decreased B cell number J:234976
enlarged spleen J:234976
increased granulocyte number J:234976
increased hematopoietic stem cell number J:234976
premature death J:208092
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(VAV1-cre)1Graf/0
involves: 129S/SvEv * C57BL/6 		abnormal common myeloid progenitor cell morphology J:174053
abnormal hematopoietic stem cell physiology J:174053
abnormal myeloid leukocyte morphology J:174053
enlarged spleen J:174053
extramedullary hematopoiesis J:174053
increased chronic myelocytic leukemia incidence J:174053
increased hematopoietic cell number J:174053
increased leukocyte cell number J:174053
increased monocyte cell number J:174053
increased spleen weight J:174053
myeloid hyperplasia J:174053
Tet2tm1.1Mjxu/Tet2+
involves: 129 * C57BL/6 		enlarged spleen J:178415
increased chronic myelocytic leukemia incidence J:178415
increased leukemia incidence J:178415
increased leukocyte cell number J:178415
increased monocyte cell number J:178415
myeloid hyperplasia J:178415
premature death J:178415
Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
involves: 129 * C57BL/6 		abnormal common myeloid progenitor cell morphology J:178415
abnormal hematopoietic stem cell physiology J:178415
anemia J:178415
enlarged liver J:178415
enlarged spleen J:178415
increased bone marrow cell number J:178415
increased chronic myelocytic leukemia incidence J:178415
increased erythrocyte cell number J:178415
increased hematopoietic stem cell number J:178415
increased hemoglobin content J:178415
increased leukemia incidence J:178415
increased leukocyte cell number J:178415
increased monocyte cell number J:178415
increased neutrophil cell number J:178415
myeloid hyperplasia J:178415
premature death J:178415
Tet2tm1.2Rao/Tet2tm1.2Rao
involves: C57BL/6NTac 		abnormal definitive hematopoiesis J:175222
abnormal myelopoiesis J:175222
increased bone marrow cell number J:175222
increased hematopoietic stem cell number J:175222
increased splenocyte number J:175222
Tet2tm1Ics/Tet2tm1Ics
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA 		abnormal common myeloid progenitor cell morphology J:174052
abnormal liver sinusoid morphology J:174052
abnormal proerythroblast morphology J:174052
abnormal spleen morphology J:174052
decreased erythrocyte cell number J:174052
decreased pre-B cell number J:174052
decreased pro-B cell number J:174052
enlarged liver J:174052
enlarged spleen J:174052
extramedullary hematopoiesis J:174052
increased B cell number J:174052
increased DN1 thymic pro-T cell number J:174052
increased double-negative T cell number J:174052
increased erythroblast number J:174052
increased hematopoietic stem cell number J:174052
increased leukocyte cell number J:174052
increased monocyte cell number J:174052
increased spleen red pulp amount J:174052
normal mortality/aging J:174052
thrombocytopenia J:174052
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory