Tet2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tet2
tet methylcytosine dioxygenase 2
MGI:2443298

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tg(Mx1-cre)1Cgn/0 involves: 129S/SvEv * C57BL/6 * CBA	abnormal myelopoiesis	J:208092
	premature death	J:208092
Asxl1^tm1.1Iaai/Asxl1^tm1.1Iaai Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tg(VAV1-cre)1Graf/0 involves: 129S/SvEv * C57BL/6	normal hematopoietic system phenotype	J:208092
Ncstn^tm1.1Akli/Ncstn^tm1.1Akli Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tg(VAV1-cre)1Graf/0 involves: 129S/SvEv * C57BL/6	abnormal common myeloid progenitor cell morphology	J:196407
	abnormal tumor pathology	J:196407
	enlarged spleen	J:196407
	increased leukemia incidence	J:196407
	increased leukocyte cell number	J:196407
	myeloid hyperplasia	J:196407
	premature death	J:196407
Sf3b1^tm1.1Mdf/Sf3b1⁺ Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tg(Mx1-cre)1Cgn/? involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J	abnormal erythroid progenitor cell morphology	J:234976
	abnormal erythropoiesis	J:234976
	abnormal megakaryocyte morphology	J:234976
	abnormal myelopoiesis	J:234976
	decreased B cell number	J:234976
	enlarged spleen	J:234976
	hypochromic macrocytic anemia	J:234976
	increased granulocyte number	J:234976
	increased hematopoietic stem cell number	J:234976
	increased mean corpuscular volume	J:234976
	macrocytosis	J:234976
Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2⁺ Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0 involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB	decreased effector memory T-helper cell number	J:333574
	normal immune system phenotype	J:333574
Tet1^tm1.2Jae/Tet1^tm1.2Jae Tet2^tm1.1Iaai/Tet2^tm1.1Iaai Tet3^tm1.1Yzhg/Tet3^tm1.1Yzhg Tg(Rorc-cre)1Litt/0 involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB	enlarged lymph nodes	J:333574
	enlarged spleen	J:333574
	increased susceptibility to autoimmune disorder	J:333574

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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