Fscn2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fscn2
fascin actin-bundling protein 2
MGI:2443337

30 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fscn2^ahl8/Fscn2^ahl8 DBA/2J	abnormal auditory brainstem response	J:139223
	decreased inner hair cell stereocilia number	J:162868
	decreased outer hair cell stereocilia number	J:162868
	increased or absent threshold for auditory brainstem response	J:162868
	increased susceptibility to age-related hearing loss	J:139223, J:162868
Fscn2^em1Fhan/Fscn2^em1Fhan C57BL/6J-Fscn2^em1Fhan	abnormal cochlear hair cell stereociliary bundle morphology	J:274170
	abnormal cochlear outer hair cell physiology	J:274170
	abnormal photoreceptor inner segment morphology	J:274170
	abnormal photoreceptor outer segment size	J:274170
	abnormal vision	J:274170
	cochlear outer hair cell degeneration	J:274170
	decreased a-wave amplitude	J:274170
	decreased b-wave amplitude	J:274170
	decreased distortion product otoacoustic emission amplitude	J:274170
	decreased total retina thickness	J:274170
	impaired hearing	J:274170
	increased or absent threshold for auditory brainstem response	J:274170
	photoreceptor inner segment degeneration	J:274170
	photoreceptor outer segment degeneration	J:274170
	retina degeneration	J:274170
	retina outer nuclear layer degeneration	J:274170
	short cochlear hair cell stereocilia	J:274170
	thin retina outer nuclear layer	J:274170
Fscn2^tm1Sykk/Fscn2⁺ involves: 129S4/SvJae * C57BL/6	abnormal cone electrophysiology	J:103713
	abnormal eye electrophysiology	J:103713
	abnormal retina morphology	J:103713
	abnormal rod electrophysiology	J:103713
	increased susceptibility to age-related retinal degeneration	J:103713
	short photoreceptor outer segment	J:103713
	thin retina inner nuclear layer	J:103713
	thin retina outer nuclear layer	J:103713
Fscn2^tm1Sykk/Fscn2^tm1Sykk involves: 129S4/SvJae * C57BL/6	abnormal cone electrophysiology	J:103713
	abnormal eye electrophysiology	J:103713
	abnormal retina morphology	J:103713
	abnormal rod electrophysiology	J:103713
	increased susceptibility to age-related retinal degeneration	J:103713
	short photoreceptor outer segment	J:103713
	thin retina inner nuclear layer	J:103713
	thin retina outer nuclear layer	J:103713
Fscn2^tm2Sykk/Fscn2⁺ involves: 129S4/SvJae * C57BL/6	abnormal cone electrophysiology	J:103713
	abnormal eye electrophysiology	J:103713
	abnormal retina morphology	J:103713
	abnormal rod electrophysiology	J:103713
	increased susceptibility to age-related retinal degeneration	J:103713
	short photoreceptor outer segment	J:103713
	thin retina inner nuclear layer	J:103713
	thin retina outer nuclear layer	J:103713
Fscn2^tm2Sykk/Fscn2^tm2Sykk involves: 129S4/SvJae * C57BL/6	abnormal cone electrophysiology	J:103713
	abnormal eye electrophysiology	J:103713
	abnormal photoreceptor outer segment morphology	J:103713
	abnormal retina morphology	J:103713
	abnormal rod electrophysiology	J:103713
	increased susceptibility to age-related retinal degeneration	J:103713
	short photoreceptor outer segment	J:103713
	thin retina inner nuclear layer	J:103713
	thin retina outer nuclear layer	J:103713
Tg(RP24-180N9)2Kjn/0 DBA/2J-Tg(RP24-180N9)2Kjn/Kjn	abnormal auditory brainstem response	J:162868

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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