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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sp8
trans-acting transcription factor 8
MGI:2443471
89 phenotypes from 5 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Tg(Msx2-cre)5Rem/0
involves: C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:223057
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
Not Specified 		normal limbs/digits/tail phenotype J:223057
Sp8tm1Aman/Sp8+
involves: 129/Sv * NMRI 		abnormal caudal vertebrae morphology J:86325
kinked tail J:86325
Sp8tm1Aman/Sp8tm1Aman
involves: 129/Sv * NMRI 		abnormal apical ectodermal ridge morphology J:86325
abnormal femur morphology J:86325
abnormal forelimb bud morphology J:86325
abnormal forelimb morphology J:86325
abnormal hindlimb morphology J:86325
abnormal humerus morphology J:86325
abnormal limb development J:86325
abnormal nose morphology J:86325
abnormal palate morphology J:86325
absent cerebellum J:86325
caudal body truncation J:86325
exencephaly J:86325
perinatal lethality, complete penetrance J:86325
short limbs J:86325
spina bifida J:86325
Sp8tm1Smb/Sp8tm1Smb
involves: 129S1/Sv * 129X1/SvJ 		abnormal anal canal morphology J:223057
abnormal craniofacial development J:200761
abnormal craniofacial morphology J:86196, J:200761
abnormal face development J:200761
abnormal forelimb morphology J:86196
abnormal frontal bone morphology J:200761
abnormal genital tubercle morphology J:223057
abnormal hindlimb morphology J:86196
abnormal interparietal bone morphology J:200761
abnormal lateral nasal prominence morphology J:200761
abnormal lumbar vertebrae morphology J:86196
abnormal maxilla morphology J:200761
abnormal maxillary prominence morphology J:200761
abnormal medial nasal prominence morphology J:200761
abnormal palatal shelf elevation J:200761
abnormal parietal bone morphology J:200761
abnormal perineum morphology J:223057
abnormal premaxilla morphology J:200761
abnormal supraoccipital bone morphology J:200761
abnormal tail morphology J:223057
abnormal vertebrae morphology J:86196
absent caudal vertebrae J:86196
absent frontal bone J:200761
absent interparietal bone J:200761
absent parietal bone J:200761
absent radius J:86196
absent sacral vertebrae J:86196
absent tail J:86196
absent tibia J:86196
adactyly J:86196
cleft palate J:200761
decreased palatal shelf size J:200761
exencephaly J:86196, J:200761
genital tubercle hypoplasia J:223057
hypospadia J:223057
incomplete caudal neuropore closure J:86196
incomplete rostral neuropore closure J:86196, J:200761
midline facial cleft J:200761
ocular hypertelorism J:200761
palatal shelves fail to meet at midline J:200761
short ulna J:86196
small maxilla J:200761
small premaxilla J:200761
small supraoccipital bone J:200761
spina bifida J:86196
Sp8tm1Smb/Sp8tm1Smb
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial development J:200761
normal craniofacial phenotype J:200761
ocular hypertelorism J:200761
Sp8tm1Smb/Sp8tm1Smb
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal limb morphology J:223057
absent fibula J:223057
absent tibia J:223057
oligodactyly J:223057
short fibula J:223057
short tibia J:223057
Sp8tm1Smb/Sp8tm2Smb
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal face development J:200761
abnormal telencephalon morphology J:200761
cleft palate J:200761
cleft upper lip J:200761
exencephaly J:200761
midline facial cleft J:200761
normal vision/eye phenotype J:200761
Sp8tm1Smb/Sp8tm2Smb
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		normal craniofacial phenotype J:200761
Sp8tm1Smb/Sp8tm2Smb
Mesp1tm2(cre)Ysa/Mesp1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal face development J:200761
normal craniofacial phenotype J:200761
midline facial cleft J:200761
Sp8tm1Smb/Sp8tm2Smb
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal face development J:200761
absent frontal bone J:200761
absent parietal bone J:200761
cleft palate J:200761
cleft upper lip J:200761
normal craniofacial phenotype J:200761
exencephaly J:200761
midline facial cleft J:200761
ocular hypertelorism J:200761
small snout J:200761
Sp8tm2.1Aman/Sp8tm2.1Aman
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal basal ganglion morphology J:160653
abnormal brain internal capsule morphology J:160653
abnormal cortical plate morphology J:160653
abnormal craniofacial morphology J:160653
abnormal forebrain development J:160653
abnormal lateral ventricle morphology J:160653
abnormal neuronal precursor proliferation J:160653
abnormal olfactory bulb development J:160653
abnormal telencephalon development J:160653
forebrain hypoplasia J:160653
holoprosencephaly J:160653
increased neuron apoptosis J:160653
neonatal lethality, complete penetrance J:160653
telencephalon hypoplasia J:160653
thin cortical plate J:160653
Sp8tm2Smb/Sp8tm2Smb
Tg(mI56i-cre,EGFP)1Kc/?
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N 		abnormal olfactory bulb external plexiform layer morphology J:107576
abnormal olfactory bulb glomerular layer morphology J:107576
abnormal olfactory bulb internal plexiform layer morphology J:107576
abnormal olfactory bulb layer morphology J:107576
normal nervous system phenotype J:107576
small olfactory bulb J:107576
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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09/03/2024
MGI 6.24 		The Jackson Laboratory