About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sp8
trans-acting transcription factor 8
MGI:2443471
89 phenotypes from 5 alleles in 10 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Tg(Msx2-cre)5Rem/0
involves: C57BL/6 * CBA 		normal limbs/digits/tail phenotype J:223057
Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+
Shhtm1(EGFP/cre)Cjt/Shh+
Not Specified 		normal limbs/digits/tail phenotype J:223057
Sp8tm1Aman/Sp8+
involves: 129/Sv * NMRI 		abnormal caudal vertebrae morphology J:86325
kinked tail J:86325
Sp8tm1Aman/Sp8tm1Aman
involves: 129/Sv * NMRI 		abnormal apical ectodermal ridge morphology J:86325
abnormal femur morphology J:86325
abnormal forelimb bud morphology J:86325
abnormal forelimb morphology J:86325
abnormal hindlimb morphology J:86325
abnormal humerus morphology J:86325
abnormal limb development J:86325
abnormal nose morphology J:86325
abnormal palate morphology J:86325
absent cerebellum J:86325
caudal body truncation J:86325
exencephaly J:86325
perinatal lethality, complete penetrance J:86325
short limbs J:86325
spina bifida J:86325
Sp8tm1Smb/Sp8tm1Smb
involves: 129S1/Sv * 129X1/SvJ 		abnormal anal canal morphology J:223057
abnormal craniofacial development J:200761
abnormal craniofacial morphology J:86196, J:200761
abnormal face development J:200761
abnormal forelimb morphology J:86196
abnormal frontal bone morphology J:200761
abnormal genital tubercle morphology J:223057
abnormal hindlimb morphology J:86196
abnormal interparietal bone morphology J:200761
abnormal lateral nasal prominence morphology J:200761
abnormal lumbar vertebrae morphology J:86196
abnormal maxilla morphology J:200761
abnormal maxillary prominence morphology J:200761
abnormal medial nasal prominence morphology J:200761
abnormal palatal shelf elevation J:200761
abnormal parietal bone morphology J:200761
abnormal perineum morphology J:223057
abnormal premaxilla morphology J:200761
abnormal supraoccipital bone morphology J:200761
abnormal tail morphology J:223057
abnormal vertebrae morphology J:86196
absent caudal vertebrae J:86196
absent frontal bone J:200761
absent interparietal bone J:200761
absent parietal bone J:200761
absent radius J:86196
absent sacral vertebrae J:86196
absent tail J:86196
absent tibia J:86196
adactyly J:86196
cleft palate J:200761
decreased palatal shelf size J:200761
exencephaly J:86196, J:200761
genital tubercle hypoplasia J:223057
hypospadia J:223057
incomplete caudal neuropore closure J:86196
incomplete rostral neuropore closure J:86196, J:200761
midline facial cleft J:200761
ocular hypertelorism J:200761
palatal shelves fail to meet at midline J:200761
short ulna J:86196
small maxilla J:200761
small premaxilla J:200761
small supraoccipital bone J:200761
spina bifida J:86196
Sp8tm1Smb/Sp8tm1Smb
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial development J:200761
normal craniofacial phenotype J:200761
ocular hypertelorism J:200761
Sp8tm1Smb/Sp8tm1Smb
Tg(Msx2-cre)5Rem/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal limb morphology J:223057
absent fibula J:223057
absent tibia J:223057
oligodactyly J:223057
short fibula J:223057
short tibia J:223057
Sp8tm1Smb/Sp8tm2Smb
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal face development J:200761
abnormal telencephalon morphology J:200761
cleft palate J:200761
cleft upper lip J:200761
exencephaly J:200761
midline facial cleft J:200761
normal vision/eye phenotype J:200761
Sp8tm1Smb/Sp8tm2Smb
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		normal craniofacial phenotype J:200761
Sp8tm1Smb/Sp8tm2Smb
Mesp1tm2(cre)Ysa/Mesp1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj 		abnormal face development J:200761
normal craniofacial phenotype J:200761
midline facial cleft J:200761
Sp8tm1Smb/Sp8tm2Smb
Pax3tm1(cre)Joe/Pax3+
involves: 129S1/Sv * 129X1/SvJ 		abnormal face development J:200761
absent frontal bone J:200761
absent parietal bone J:200761
cleft palate J:200761
cleft upper lip J:200761
normal craniofacial phenotype J:200761
exencephaly J:200761
midline facial cleft J:200761
ocular hypertelorism J:200761
small snout J:200761
Sp8tm2.1Aman/Sp8tm2.1Aman
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal basal ganglion morphology J:160653
abnormal brain internal capsule morphology J:160653
abnormal cortical plate morphology J:160653
abnormal craniofacial morphology J:160653
abnormal forebrain development J:160653
abnormal lateral ventricle morphology J:160653
abnormal neuronal precursor proliferation J:160653
abnormal olfactory bulb development J:160653
abnormal telencephalon development J:160653
forebrain hypoplasia J:160653
holoprosencephaly J:160653
increased neuron apoptosis J:160653
neonatal lethality, complete penetrance J:160653
telencephalon hypoplasia J:160653
thin cortical plate J:160653
Sp8tm2Smb/Sp8tm2Smb
Tg(mI56i-cre,EGFP)1Kc/?
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N 		abnormal olfactory bulb external plexiform layer morphology J:107576
abnormal olfactory bulb glomerular layer morphology J:107576
abnormal olfactory bulb internal plexiform layer morphology J:107576
abnormal olfactory bulb layer morphology J:107576
normal nervous system phenotype J:107576
small olfactory bulb J:107576
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory