Sp8 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sp8
trans-acting transcription factor 8
MGI:2443471

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Gt(ROSA)26Sor^tm2(Sp8)Lma/Gt(ROSA)26Sor⁺ Tg(Msx2-cre)5Rem/0 involves: 129X1/SvJ * C57BL/6 * CBA	normal limbs/digits/tail phenotype	J:223057
Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Sp8^tm1Smb/Sp8^tm1Smb Tg(Msx2-cre)5Rem/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	normal limbs/digits/tail phenotype	J:223057
Gt(ROSA)26Sor^tm2(Sp8)Lma/Gt(ROSA)26Sor⁺ Sp8^tm1Smb/Sp8^tm1Smb Tg(Msx2-cre)5Rem/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	abnormal autopod morphology	J:223057
	abnormal limb morphology	J:223057
Gt(ROSA)26Sor^tm2Sho/Gt(ROSA)26Sor⁺ Sp8^tm1Smb/Sp8^tm1Smb H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J	abnormal nasal pit morphology	J:200761
	decreased cranial neural crest cell proliferation	J:200761
	increased cranial neural crest cell apoptosis	J:200761
	increased embryonic neuroepithelium apoptosis	J:200761
	increased head mesenchyme apoptosis	J:200761
lgl/lgl⁺ Sp8^tm1Smb/Sp8⁺ involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6	abnormal craniofacial morphology	J:86196
	abnormal forelimb morphology	J:86196
	abnormal hindlimb morphology	J:86196
	abnormal radius morphology	J:86196
	abnormal tail morphology	J:86196
	abnormal ulna morphology	J:86196
	absent fibula	J:86196
	absent tibia	J:86196
	adactyly	J:86196
	caudal vertebral fusion	J:86196
	encephalomeningocele	J:86196
	exencephaly	J:86196
	incomplete rostral neuropore closure	J:86196
	perinatal lethality	J:86196

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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