Setx Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Setx
senataxin
MGI:2443480

28 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Setx^tm1.1Als/Setx⁺ involves: 129 * C57BL/6J	abnormal motor capabilities/coordination/movement	J:320844
	abnormal motor neuron morphology	J:320844
	abnormal neuromuscular synapse morphology	J:320844
	abnormal neuron physiology	J:320844
	impaired coordination	J:320844
	increased susceptibility to neuronal excitotoxicity	J:320844
	limb grasping	J:320844
	motor neuron degeneration	J:320844
Setx^tm1.1Mfl/Setx^tm1.1Mfl Not Specified	abnormal double-strand DNA break repair	J:223053
	abnormal male meiosis	J:223053
	abnormal seminiferous tubule epithelium morphology	J:223053
	abnormal seminiferous tubule morphology	J:223053
	abnormal spermiogenesis	J:223053
	arrest of male meiosis	J:223053
	azoospermia	J:223053
	globozoospermia	J:223053
	increased male germ cell apoptosis	J:223053
	male infertility	J:223053
	reduced female fertility	J:223053
	small testis	J:223053
Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics	decreased leukocyte cell number	J:211773
	decreased lymphocyte cell number	J:211773
	decreased total retina thickness	J:211773
	improved glucose tolerance	J:211773
	increased eosinophil cell number	J:211773
	increased monocyte cell number	J:211773
	increased neutrophil cell number	J:211773
	increased NK cell number	J:211773
	male infertility	J:211773
	small testis	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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