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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Slc9a6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
MGI:2443511
31 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Slc9a6tm1Dgen/Y
B6.129P2-Slc9a6tm1Dgen/J 		abnormal amygdala morphology J:229166, J:241124
abnormal brain morphology J:241124
abnormal cerebellar molecular layer J:229166
abnormal cerebellum morphology J:262453
abnormal cerebral hemisphere morphology J:262453
abnormal enzyme/coenzyme activity J:241124
abnormal hippocampus morphology J:262453
abnormal neuron morphology J:241124
abnormal Purkinje cell axon morphology J:241124
abnormal spatial reference memory J:229166
astrocytosis J:262453
ataxia J:229166
normal behavior/neurological phenotype J:241124
decreased brain size J:262453
decreased striatum size J:262453
gliosis J:229166
impaired coordination J:229166, J:241124
increased ganglioside level J:229166, J:241124
increased locomotor activity J:229166, J:241124
increased vertical activity J:241124
microgliosis J:262453
Purkinje cell degeneration J:229166, J:241124, J:262453
small cerebellum J:262453
thin cerebral cortex J:262453
Slc9a6tm1Dgen/Slc9a6+
B6.129P2-Slc9a6tm1Dgen/J 		abnormal amygdala morphology J:229166
abnormal hippocampus CA3 region morphology J:229166
abnormal hippocampus CA4 region morphology J:229166
abnormal spatial reference memory J:229166
decreased Purkinje cell number J:262453
gliosis J:229166
impaired coordination J:229166
increased ganglioside level J:229166
Purkinje cell degeneration J:229166
Slc9a6tm1Dgen/Y
involves: 129P2/OlaHsd * C57BL/6 		increased locomotor activity J:101679
increased susceptibility to pharmacologically induced seizures J:101679
Slc9a6tm1Dgen/Slc9a6tm1Dgen
B6.129P2-Slc9a6tm1Dgen/J 		abnormal amygdala morphology J:241124
abnormal brain cholesterol level J:241124
abnormal brain morphology J:241124
abnormal cerebral cortex morphology J:241124
abnormal enzyme/coenzyme activity J:241124
abnormal neuron morphology J:241124
abnormal Purkinje cell axon morphology J:241124
normal behavior/neurological phenotype J:241124
increased ganglioside level J:241124
postnatal lethality, incomplete penetrance J:241124
Purkinje cell degeneration J:241124
Slc9a6tm1Tigm/Y
B6J.Cg-Slc9a6tm1Tigm 		decreased Purkinje cell number J:262453
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory