Ambra1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ambra1
autophagy/beclin 1 regulator 1
MGI:2443564

24 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ambra1^em1(IMPC)Bay/Ambra1⁺ C57BL/6N-Ambra1^em1(IMPC)Bay/BayMmucd	abnormal eye anterior chamber depth	J:211773
	abnormal retina inner nuclear layer morphology	J:211773
	abnormal retina morphology	J:211773
	decreased prepulse inhibition	J:211773
	increased total retina thickness	J:211773
Ambra1^em1(IMPC)Bay/Ambra1^em1(IMPC)Bay C57BL/6N-Ambra1^em1(IMPC)Bay/BayMmucd	abnormal cranium morphology	J:211773
	abnormal hindbrain morphology	J:211773
	abnormal midbrain morphology	J:211773
	abnormal neural tube closure	J:211773
	abnormal tail morphology	J:211773
	facial cleft	J:211773
	prenatal lethality	J:211773
	preweaning lethality, complete penetrance	J:211773
	spina bifida	J:211773
Ambra1^{Gt(pGT1.8geo)1Fcec}/Ambra1^{Gt(pGT1.8geo)1Fcec} involves: C57BL/6	abnormal neural fold formation	J:122795
	abnormal telencephalon development	J:122795
	embryonic lethality during organogenesis, incomplete penetrance	J:122795
	exencephaly	J:122795
	impaired autophagy	J:122795
	increased cell proliferation	J:122795
	increased embryonic neuroepithelial cell proliferation	J:122795
	increased embryonic neuroepithelium apoptosis	J:122795
	increased spinal cord size	J:122795
	lethality throughout fetal growth and development, complete penetrance	J:122795
	spina bifida	J:122795
Ambra1^{Gt(pGT1.8geo)1Fcec}/Ambra1^{Gt(pGT1.8geo)1Fcec} involves: CD-1 * NMRI	embryonic lethality during organogenesis, incomplete penetrance	J:122795
	exencephaly	J:122795
	spina bifida	J:122795

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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