Lefty2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lefty2
left-right determination factor 2
MGI:2443573

31 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lefty2^tm1Hmd/Lefty2^tm1Hmd involves: 129P2/OlaHsd * C57BL/6Cr	abnormal developmental patterning	J:57907
	abnormal ectoderm development	J:57907
	abnormal embryo development	J:57907
	abnormal head fold morphology	J:57907
	abnormal primitive streak morphology	J:57907
	abnormal visceral yolk sac morphology	J:57907
	absent heart	J:57907
	absent notochord	J:57907
	absent primitive node	J:57907
	absent somites	J:57907
	absent vitelline blood vessels	J:57907
	embryonic lethality during organogenesis, complete penetrance	J:57907
	failure of chorioallantoic fusion	J:57907
Lefty2^tm2Hmd/Lefty2^tm2Hmd involves: 129P2/OlaHsd * C57BL/6	abnormal heart and great artery attachment	J:70483
	abnormal heart morphology	J:70483
	abnormal hepatic portal vein morphology	J:70483
	abnormal inferior vena cava morphology	J:70483
	abnormal large intestine placement	J:70483
	abnormal left-right axis patterning	J:70483
	abnormal liver morphology	J:70483
	absent heart right ventricle	J:70483
	accessory spleen	J:70483
	complete atrioventricular septal defect	J:70483
	dextrocardia	J:70483
	double outlet right ventricle	J:70483
	left atrial isomerism	J:70483
	left-sided isomerism	J:70483
	postnatal lethality, incomplete penetrance	J:70483
	normal respiratory system phenotype	J:70483
	transposition of great arteries	J:70483
	tricuspid valve atresia	J:70483

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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