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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sgms1
sphingomyelin synthase 1
MGI:2444110
46 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sgms1Gt(E201D11)Wrst/Sgms1Gt(E201D11)Wrst
B6.129P2-Sgms1Gt(E201D11)Wrst 		abnormal ceramide level J:249941
abnormal lipid level J:249941
abnormal Sertoli cell barrier function J:249941
abnormal Sertoli cell barrier morphology J:249941
abnormal spermatid morphology J:249941
abnormal spermatogenesis J:249941
abnormal sphingolipid level J:249941
abnormal sphingomyelin level J:249941
absent acrosome J:249941
absent sperm flagellum J:249941
decreased body weight J:249941
decreased litter size J:249941
decreased liver weight J:249941
decreased male germ cell number J:249941
decreased plasmalogen level J:249941
decreased unsaturated fatty acids level J:249941
increased testis apoptosis J:249941
male infertility J:249941
reduced male fertility J:249941
seminiferous tubule degeneration J:249941
Sgms1tm1a(EUCOMM)Wtsi/Sgms1tm1a(EUCOMM)Wtsi
C57BL/6N-Sgms1tm1a(EUCOMM)Wtsi/Wtsi 		decreased mean corpuscular hemoglobin J:211773
decreased total body fat amount J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating creatinine level J:211773
increased circulating magnesium level J:211773
increased grip strength J:211773
increased lean body mass J:211773
increased mean platelet volume J:211773
male infertility J:211773
thrombocytopenia J:211773
tremors J:211773
Sgms1tm1Jia/Sgms1tm1Jia
involves: C57BL/6 		abnormal ceramide level J:201497
abnormal cytokine level J:201497
abnormal cytokine secretion J:201497
abnormal sphingomyelin level J:201497
decreased circulating interleukin-6 level J:201497
decreased circulating tumor necrosis factor level J:201497
decreased interleukin-6 secretion J:201497
decreased tumor necrosis factor secretion J:201497
normal homeostasis/metabolism phenotype J:201497
Sgms1tm1Kenw/Sgms1tm1Kenw
involves: 129S2/SvPas * C57BL/6 		abnormal pancreatic islet morphology J:168726
decreased body weight J:168726
decreased circulating insulin level J:168726
decreased insulin secretion J:168726
decreased white adipose tissue amount J:168726
hyperglycemia J:168726
impaired glucose tolerance J:168726
increased insulin sensitivity J:168726
oxidative stress J:168726
premature death J:168726
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory