About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Glis3
GLIS family zinc finger 3
MGI:2444289
29 phenotypes from 3 alleles in 3 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Glis3tm1.2Chan/Glis3+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		decreased circulating insulin level J:177082
decreased insulin secretion J:177082
Glis3tm1.2Chan/Glis3tm1.2Chan
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		absent pancreatic alpha cells J:177082
absent pancreatic beta cells J:177082
decreased body size J:177082
decreased circulating insulin level J:177082
decreased insulin secretion J:177082
decreased pancreatic alpha cell number J:177082
decreased pancreatic beta cell number J:177082
decreased pancreatic delta cell number J:177082
decreased pancreatic epsilon cell number J:177082
dehydration J:177082
disorganized pancreatic islets J:177082
normal endocrine/exocrine gland phenotype J:177082
hyperglycemia J:177082
increased circulating glucose level J:177082
increased circulating ketone body level J:177082
postnatal growth retardation J:177082
postnatal lethality, complete penetrance J:177082
small pancreatic islets J:177082
Glis3tm1Amj/Glis3tm1Amj
involves: 129 * C57BL/6 		abnormal renal tubule epithelial cell primary cilium morphology J:148994
decreased birth weight J:148994
dilated renal tubule J:148994
hyperglycemia J:148994
increased circulating insulin level J:148994
increased glomerular capsule space J:148994
polycystic kidney J:148994
postnatal lethality, complete penetrance J:148994
Glis3tm1Hiha/Glis3tm1Hiha
involves: C57BL/6 * CBA 		abnormal pancreas physiology J:150077
abnormal pancreatic islet morphology J:150077
decreased activity of thyroid gland J:150077
decreased pancreatic alpha cell number J:150077
decreased pancreatic beta cell number J:150077
decreased pancreatic delta cell number J:150077
impaired glucose tolerance J:150077
increased circulating glucose level J:150077
kidney cortex cyst J:150077
polycystic kidney J:150077
postnatal growth retardation J:150077
postnatal lethality, complete penetrance J:150077
small pancreatic islets J:150077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory