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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Glis3
GLIS family zinc finger 3
MGI:2444289
29 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Glis3tm1.2Chan/Glis3+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		decreased circulating insulin level J:177082
decreased insulin secretion J:177082
Glis3tm1.2Chan/Glis3tm1.2Chan
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		absent pancreatic alpha cells J:177082
absent pancreatic beta cells J:177082
decreased body size J:177082
decreased circulating insulin level J:177082
decreased insulin secretion J:177082
decreased pancreatic alpha cell number J:177082
decreased pancreatic beta cell number J:177082
decreased pancreatic delta cell number J:177082
decreased pancreatic epsilon cell number J:177082
dehydration J:177082
disorganized pancreatic islets J:177082
normal endocrine/exocrine gland phenotype J:177082
hyperglycemia J:177082
increased circulating glucose level J:177082
increased circulating ketone body level J:177082
postnatal growth retardation J:177082
postnatal lethality, complete penetrance J:177082
small pancreatic islets J:177082
Glis3tm1Amj/Glis3tm1Amj
involves: 129 * C57BL/6 		abnormal renal tubule epithelial cell primary cilium morphology J:148994
decreased birth weight J:148994
dilated renal tubule J:148994
hyperglycemia J:148994
increased circulating insulin level J:148994
increased glomerular capsule space J:148994
polycystic kidney J:148994
postnatal lethality, complete penetrance J:148994
Glis3tm1Hiha/Glis3tm1Hiha
involves: C57BL/6 * CBA 		abnormal pancreas physiology J:150077
abnormal pancreatic islet morphology J:150077
decreased activity of thyroid gland J:150077
decreased pancreatic alpha cell number J:150077
decreased pancreatic beta cell number J:150077
decreased pancreatic delta cell number J:150077
impaired glucose tolerance J:150077
increased circulating glucose level J:150077
kidney cortex cyst J:150077
polycystic kidney J:150077
postnatal growth retardation J:150077
postnatal lethality, complete penetrance J:150077
small pancreatic islets J:150077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory