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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Sh3tc2
SH3 domain and tetratricopeptide repeats 2
MGI:2444417
15 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Sh3tc2m1J/Sh3tc2m1J
B6.Cg-Sh3tc2m1J/GrsrRwb 		abnormal Schwann cell morphology J:229591, J:240096
decreased grip strength J:240096
decreased myelin sheath thickness J:229591, J:240096
decreased nerve conduction velocity J:229591, J:240096
demyelination J:240096
heart block J:240096
normal nervous system phenotype J:240096
tremors J:240096
Sh3tc2tm1.1Rchr/Sh3tc2tm1.1Rchr
involves: 129/Sv * FVB/N 		abnormal axon morphology J:153705
abnormal myelination J:153705
abnormal node of Ranvier morphology J:153705
decreased nerve conduction velocity J:153705
limb grasping J:153705
neurodegeneration J:153705
normal skeleton phenotype J:153705
Sh3tc2tm1b(KOMP)Wtsi/Sh3tc2tm1b(KOMP)Wtsi
C57BL/6N-Sh3tc2tm1b(KOMP)Wtsi/J 		decreased circulating glucose level J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory