Pptc7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pptc7
PTC7 protein phosphatase homolog
MGI:2444593

17 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pptc7^em1Pagd/Pptc7^em1Pagd C57BL/6J-Pptc7^em1Pagd	abnormal glucose homeostasis	J:277086
	abnormal heart morphology	J:277086
	abnormal hepatocyte mitochondrial morphology	J:277086
	abnormal liver morphology	J:277086
	abnormal mitochondrial biogenesis	J:277086
	abnormal mitochondrial physiology	J:277086
	abnormal myocardial fiber mitochondrial morphology	J:277086
	decreased birth weight	J:277086
	decreased circulating ketone body level	J:277086
	decreased fetal weight	J:277086
	hypoglycemia	J:277086
	increased circulating lactate level	J:277086
	neonatal lethality, complete penetrance	J:277086
Pptc7^em2Pagd/Pptc7^em2Pagd C57BL/6J-Pptc7^em2Pagd	abnormal glucose homeostasis	J:277086
	abnormal heart morphology	J:277086
	abnormal hepatocyte mitochondrial morphology	J:277086
	abnormal liver morphology	J:277086
	abnormal mitochondrial biogenesis	J:277086
	abnormal mitochondrial physiology	J:277086
	abnormal myocardial fiber mitochondrial morphology	J:277086
	decreased birth weight	J:277086
	decreased circulating ketone body level	J:277086
	decreased fetal weight	J:277086
	hypoglycemia	J:277086
	increased circulating lactate level	J:277086
	neonatal lethality, complete penetrance	J:277086
Pptc7^{tm1b(EUCOMM)Hmgu}/Pptc7⁺ C57BL/6N-Pptc7^{tm1b(EUCOMM)Hmgu}/Bay	abnormal coat appearance	J:211773
	unresponsive to tactile stimuli	J:211773
Pptc7^{tm1b(EUCOMM)Hmgu}/Pptc7^{tm1b(EUCOMM)Hmgu} C57BL/6N-Pptc7^{tm1b(EUCOMM)Hmgu}/Bay	abnormal embryo size	J:211773
	preweaning lethality, incomplete penetrance	J:211773
	unresponsive to tactile stimuli	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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