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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nlgn3
neuroligin 3
MGI:2444609
44 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nlgn3em1(IMPC)Rbrc/Y
C57BL/6NJcl-Nlgn3em1(IMPC)Rbrc/Rbrc 		abnormal blood uric acid level J:211773
abnormal locomotor activation J:211773
hyperactivity J:211773
increased bone mineral density J:211773
increased eosinophil cell number J:211773
Nlgn3em1(IMPC)Rbrc/Nlgn3em1(IMPC)Rbrc
C57BL/6NJcl-Nlgn3em1(IMPC)Rbrc/Rbrc 		decreased anxiety-related response J:211773
hyperactivity J:211773
Nlgn3tm1.1Htz/Y
involves: C57BL/6 * FVB/N 		abnormal motor coordination/balance J:167116
abnormal righting response J:167116
abnormal spatial learning J:167116
decreased startle reflex J:167116
decreased vertical activity J:167116
decreased vocalization J:167116
enhanced coordination J:167116
impaired coordination J:167116
increased growth rate J:167116
increased thigmotaxis J:167116
normal nervous system phenotype J:167116
Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
involves: C57BL/6 * FVB/N 		abnormal learning/memory/conditioning J:167116
abnormal righting response J:167116
abnormal spatial learning J:167116
increased thigmotaxis J:167116
postnatal growth retardation J:167116
Nlgn3tm1Bros/Nlgn3tm1Bros
B6.Cg-Nlgn3tm1Bros 		abnormal social investigation J:151116
normal behavior/neurological phenotype J:151116
decreased brain size J:151116
decreased vocalization J:151116
impaired contextual conditioning behavior J:151116
impaired cued conditioning behavior J:151116
impaired olfaction J:151116
increased exploration in new environment J:151116
increased locomotor activity J:151116
normal nervous system phenotype J:151116
Nlgn3tm1Rhn/Y
involves: 129S6/SvEvTac * C57BL/6 		abnormal miniature excitatory postsynaptic currents J:187744
abnormal motor coordination/balance J:187744
absent long-term depression J:187744
impaired synaptic plasticity J:187744
increased CNS synapse formation J:187744
increased excitatory postsynaptic current amplitude J:187744
Nlgn3tm1Rhn/Y
Tg(Pcp2-tTA)3Horr/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal nervous system phenotype J:187744
Nlgn3tm1Sud/Y
involves: 129S1/Sv * 129X1/SvJ 		enhanced learning J:214636
increased locomotor activity J:214636
increased stereotypic behavior J:214636
Nlgn3tm1Sud/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal inhibitory postsynaptic currents J:125344
abnormal social investigation J:125344
abnormal spatial learning J:125344
Nlgn3tm1Sud/Y
Tg(Drd1-cre)EY262Gsat/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		enhanced learning J:214636
increased stereotypic behavior J:214636
Nlgn3tm1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased miniature inhibitory postsynaptic current frequency J:214636
Nlgn3tm2.1Sud/Y
involves: 129S1/Sv * 129X1/SvJ 		enhanced learning J:214636
increased locomotor activity J:214636
increased stereotypic behavior J:214636
increased vertical activity J:214636
stereotypic behavior J:214636
Nlgn3tm2.1Sud/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:125344
Nlgn3tm2.1Sud/Y
Tg(Drd1-tdTomato)5Calak/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased miniature inhibitory postsynaptic current frequency J:214636
Nlgn3tm3.1Sud/Nlgn3tm3.1Sud
involves: 129S1/Sv * 129X1/SvJ 		abnormal excitatory postsynaptic potential J:184114
abnormal glutamate-mediated receptor currents J:184114
abnormal miniature excitatory postsynaptic currents J:184114
normal nervous system phenotype J:184114
reduced AMPA-mediated synaptic currents J:184114
Nlgn3tm4.1Sud/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		enhanced learning J:214636
hyperactivity J:214636
Nlgn3tm4.1Sud/Y
Pvalbtm1(cre)Arbr/Pvalb+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		decreased locomotor activity J:214636
Nlgn3tm4.1Sud/Y
Tg(Adora2a-cre)2MDkde/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		normal behavior/neurological phenotype J:214636
Nlgn3tm4.1Sud/Y
Tg(Drd1-cre)EY262Gsat/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		enhanced learning J:214636
hyperactivity J:214636
Nlgn3tm4.1Sud/Y
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased locomotor activity J:214636
Nlgn3tm4.1Sud/Y
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased locomotor activity J:214636
Nlgn3tm4.1Sud/Y
Tg(Pcp2-cre)2Mpin/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac 		decreased excitatory postsynaptic current amplitude J:227671
normal nervous system phenotype J:227671
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory