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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fnip1
folliculin interacting protein 1
MGI:2444668
80 phenotypes from 8 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fnip1em1(IMPC)Ccpcz/Fnip1+
C57BL/6NCrl-Fnip1em1(IMPC)Ccpcz/Ccpcz 		abnormal inspiratory capacity J:211773
abnormal mammary gland morphology J:211773
abnormal thymus morphology J:211773
decreased lung elastance J:211773
decreased lung tissue damping J:211773
increased fasting circulating glucose level J:211773
increased freezing behavior J:211773
increased lung compliance J:211773
small thymus J:211773
thick ventricular wall J:211773
Fnip1em1(IMPC)Ccpcz/Fnip1em1(IMPC)Ccpcz
C57BL/6NCrl-Fnip1em1(IMPC)Ccpcz/Ccpcz 		abnormal cecum morphology J:211773
abnormal heart morphology J:211773
abnormal inspiratory capacity J:211773
abnormal pancreas morphology J:211773
abnormal skeletal muscle morphology J:211773
abnormal spine curvature J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
decreased airway resistance J:211773
decreased body weight J:211773
decreased grip strength J:211773
decreased heart rate J:211773
decreased locomotor activity J:211773
decreased lung elastance J:211773
decreased lung tissue damping J:211773
decreased lymphocyte cell number J:211773
decreased red blood cell distribution width J:211773
decreased respiratory quotient J:211773
decreased spleen weight J:211773
decreased startle reflex J:211773
dilated aorta J:211773
dilated heart left ventricle J:211773
enlarged cecum J:211773
enlarged heart J:211773
enlarged thymus J:211773
improved glucose tolerance J:211773
increased cardiac muscle contractility J:211773
increased cardiac stroke volume J:211773
increased circulating iron level J:211773
increased fasting circulating glucose level J:211773
increased heart left ventricle size J:211773
increased heart weight J:211773
increased liver weight J:211773
increased lung compliance J:211773
increased neutrophil cell number J:211773
increased thigmotaxis J:211773
small spleen J:211773
thick ventricular wall J:211773
Fnip1Gt(RRM154)Byg/Fnip1Gt(RRM154)Byg
involves: 129P2/OlaHsd * C57BL/6J 		absent B cells J:189078
absent B-2 B cells J:189078
arrested B cell differentiation J:189078
decreased B cell number J:189078
decreased B-1 B cell number J:189078
decreased mature B cell number J:189078
decreased pre-B cell number J:189078
decreased transitional stage B cell number J:189078
increased B cell apoptosis J:189078
increased pro-B cell number J:189078
normal renal/urinary system phenotype J:189078
small spleen J:189078
Fnip1LPAB.1/Fnip1LPAB.1
C57BL/6J-Fnip1LPAB.1 		abnormal B cell physiology J:187318
abnormal skeletal muscle morphology J:187318
absent B cells J:187318
arrested B cell differentiation J:187318
cardiomyopathy J:187318
decreased B-1 B cell number J:187318
decreased IgE level J:187318
decreased IgG1 level J:187318
decreased IgG2a level J:187318
decreased IgG level J:187318
decreased IgM level J:187318
increased B cell apoptosis J:187318
increased liver glycogen level J:187318
Fnip1m1Btlr/Fnip1m1Btlr
C57BL/6J-Fnip1m1Btlr 		abnormal bone marrow cell number J:234285
abnormal skeletal muscle morphology J:234285
abnormal splenocyte morphology J:234285
absent B cells J:234285
cardiac hypertrophy J:234285
normal cardiovascular system phenotype J:234285
decreased IgM level J:234285
decreased marginal zone B cell number J:234285
enhanced autophagy J:234285
enlarged heart J:234285
impaired hematopoiesis J:234285
increased cardiac muscle glycogen level J:234285
prolonged QRS complex duration J:234285
shortened PR interval J:234285
Fnip1m2Btlr/Fnip1m2Btlr
C57BL/6J-Fnip1m2Btlr 		decreased B cell number J:265134
increased B-1 B cell number J:265134
increased CD4-positive, alpha-beta T cell number J:265134
increased single-positive T cell number J:265134
increased T cell number J:265134
Fnip1M3Btlr/Fnip1M3Btlr
C57BL/6J-Fnip1M3Btlr 		abnormal B cell differentiation J:272802
Fnip1tm1.1Baba/Fnip1tm1.1Baba
Tg(Cdh16-cre)91Igr/0
involves: C57BL/6 * ICR 		kidney cyst J:220672
Fnip1tm1.1Baba/Fnip1tm1.1Baba
Tg(Ckmm-cre)5Khn/0
involves: C57BL/6 * FVB 		abnormal mitochondrial physiology J:220672
abnormal muscle morphology J:220672
abnormal muscle physiology J:220672
cardiac hypertrophy J:220672
Fnip1tm1.2Baba/Fnip1tm1.2Baba
involves: C57BL/6 		premature death J:220672
Fnip1tm1.2Baba/Fnip1tm1.2Baba
involves: C57BL/6 * C57BL/6J * FVB/N * SJL 		absent B cells J:189078
absent B-2 B cells J:189078
arrested B cell differentiation J:189078
decreased B cell number J:189078
decreased B-1 B cell number J:189078
decreased mature B cell number J:189078
decreased pre-B cell number J:189078
decreased transitional stage B cell number J:189078
increased B cell apoptosis J:189078
increased pro-B cell number J:189078
normal renal/urinary system phenotype J:189078
small spleen J:189078
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory