Madd Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Madd
MAP-kinase activating death domain
MGI:2444672

20 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Madd^tm1Bpra/Madd^tm1Bpra Tg(Ins2-cre/ERT)1Dam/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal pancreas morphology	J:225256
	abnormal pancreatic beta cell morphology	J:225256
	abnormal pancreatic beta cell physiology	J:225256
	abnormal pancreatic islet morphology	J:225256
	decreased circulating insulin level	J:225256
	decreased insulin secretion	J:225256
	hyperglycemia	J:225256
	impaired glucose tolerance	J:225256
	increased fasting circulating glucose level	J:225256
Madd^tm1Ytk/Madd^tm1Ytk involves: 129X1/SvJ	abnormal excitatory postsynaptic currents	J:126302
	abnormal miniature excitatory postsynaptic currents	J:126302
	abnormal synaptic vesicle morphology	J:126302
	biphasic excitatory postsynaptic current amplitude	J:126302
Madd^tm1Ytk/Madd^tm1Ytk involves: 129X1/SvJ * C57BL/6 * DBA/2	abnormal neuromuscular synapse morphology	J:126869
	abnormal synaptic vesicle morphology	J:126869
	abnormal synaptic vesicle number	J:126869
	hyporesponsive to tactile stimuli	J:126869
	impaired ability to fire action potentials	J:126869
	neonatal lethality, complete penetrance	J:126869
	primary atelectasis	J:126869
	respiratory failure	J:126869

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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