Smcr8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Smcr8
Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
MGI:2444720

12 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Smcr8^em1Btlr/Smcr8^em1Btlr C57BL/6J-Smcr8^em1Btlr	abnormal lysosome morphology	J:268243
	abnormal lysosome physiology	J:268243
	enlarged lymph nodes	J:268243
	enlarged spleen	J:268243
	increased CD4-positive, alpha-beta T cell number	J:268243
	increased CD8-positive, alpha-beta T cell number	J:268243
	increased circulating interleukin-12b level	J:268243
	increased interleukin-6 secretion	J:268243
	increased susceptibility to induced colitis	J:268243
	increased tumor necrosis factor secretion	J:268243
Smcr8^em2Btlr/Smcr8^em2Btlr C57BL/6J-Smcr8^em2Btlr	enlarged lymph nodes	J:268243
	enlarged spleen	J:268243
	increased CD4-positive, alpha-beta T cell number	J:268243
	increased CD8-positive, alpha-beta T cell number	J:268243
	increased circulating interleukin-12b level	J:268243
	increased interleukin-6 secretion	J:268243
	increased susceptibility to induced colitis	J:268243
	increased tumor necrosis factor secretion	J:268243
Smcr8^m1Btlr/Smcr8⁺ C57BL/6J-Smcr8^m1Btlr	increased susceptibility to induced colitis	J:268243
Smcr8^m1Btlr/Smcr8^m1Btlr C57BL/6J-Smcr8^m1Btlr	increased susceptibility to induced colitis	J:268243
Smcr8^m1Btlr/Smcr8^m1Btlr C57BL/6J-Smcr8^m1Btlr	increased tumor necrosis factor secretion	J:268243
Smcr8^m2Btlr/Smcr8^m2Btlr C57BL/6J-Smcr8^m2Btlr	increased susceptibility to induced colitis	J:268243
Smcr8^m2Btlr/Smcr8^m2Btlr C57BL/6J-Smcr8^m2Btlr	increased tumor necrosis factor secretion	J:268243
Smcr8^m3Btlr/Smcr8^m3Btlr C57BL/6J-Smcr8^m3Btlr	increased susceptibility to induced colitis	J:268243
Smcr8^m3Btlr/Smcr8^m3Btlr C57BL/6J-Smcr8^m3Btlr	increased tumor necrosis factor secretion	J:268243
Smcr8^{tm1(KOMP)Vlcg}/Smcr8^{tm1(KOMP)Vlcg} involves: 129S1/SvImJ * C57BL/6NTac	abnormal autophagy	J:236977
	abnormal lysosome physiology	J:236977
	abnormal protein level	J:236977
Smcr8^{tm1.1(KOMP)Vlcg}/Smcr8^{tm1.1(KOMP)Vlcg} involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac	abnormal autophagy	J:236977
	abnormal lysosome physiology	J:236977
	abnormal protein level	J:236977

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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