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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chd7
chromodomain helicase DNA binding protein 7
MGI:2444748
360 phenotypes from 22 alleles in 50 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Chd7Coa1/Chd7+
involves: C57BL/6J 		abnormal brain development J:187010
abnormal corpus callosum morphology J:187010
abnormal embryonic neuroepithelium morphology J:187010
abnormal eye morphology J:187010
abnormal frontal lobe morphology J:187010
abnormal hippocampus morphology J:187010
abnormal neocortex morphology J:187010
abnormal olfactory lobe morphology J:187010
abnormal parietal lobe morphology J:187010
abnormal telencephalon development J:187010
abnormal telencephalon morphology J:187010
absent hippocampus J:187010
absent olfactory bulb J:187010
circling J:187010
decreased body size J:187010
decreased body weight J:187010
dilated lateral ventricle J:187010
dilated third ventricle J:187010
head bobbing J:187010
hydrocephaly J:187010
hyperactivity J:187010
impaired hearing J:187010
lethality throughout fetal growth and development, incomplete penetrance J:187010
postnatal growth retardation J:187010
premature death J:187010
preweaning lethality, incomplete penetrance J:187010
reduced fertility J:187010
small hippocampus J:187010
small olfactory bulb J:187010
Chd7Coa1/Chd7Coa1
involves: C57BL/6J 		embryonic lethality during organogenesis, complete penetrance J:187010
Chd7Cycn/Chd7+
involves: BALB/c * C3H/HeN 		abnormal lateral semicircular canal morphology J:75619
abnormal posterior semicircular canal morphology J:75619
circling J:63816
decreased body size J:75619
head tossing J:75619
Chd7Dz/Chd7+
involves: BALB/c * C3H/HeN 		abnormal lateral semicircular canal morphology J:75619
abnormal posterior semicircular canal morphology J:75619
circling J:63816
decreased body size J:75619
head tossing J:75619
Chd7Edy/Chd7+
involves: BALB/c * C3H/HeN 		abnormal incudomalleolar joint morphology J:75619
abnormal incus morphology J:75619
abnormal lateral semicircular canal morphology J:75619
abnormal malleus morphology J:75619
abnormal posterior semicircular canal morphology J:75619
abnormal stapes crus morpholgy J:75619
abnormal stapes morphology J:75619
circling J:63816
decreased body size J:75619
decreased cochlear nerve compound action potential J:75619
head tossing J:75619
Chd7em1Jiao/Chd7em1Jiao
involves: 129S6/SvEvTac * C57BL/6 * SJL 		embryonic growth arrest J:298597
embryonic growth retardation J:298597
embryonic lethality during organogenesis, complete penetrance J:298597
Chd7em1Kangn/Chd7em1Kangn
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * SJL/J 		abnormal bone marrow cell physiology J:336448
abnormal compact bone morphology J:336448
abnormal craniofacial bone morphology J:336448
abnormal trabecular bone morphology J:336448
decreased body size J:336448
decreased body weight J:336448
decreased bone mass J:336448
decreased bone mineral density J:336448
decreased bone mineralization J:336448
decreased bone ossification J:336448
decreased bone trabecula number J:336448
decreased femur compact bone thickness J:336448
decreased long bone epiphyseal plate size J:336448
decreased osteoblast cell number J:336448
decreased trabecular bone thickness J:336448
decreased volumetric bone mineral density J:336448
increased bone marrow adipose tissue amount J:336448
increased bone trabecular spacing J:336448
premature death J:336448
short limbs J:336448
Chd7em1Kangn/Chd7em1Kangn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: C57BL/6J * CD-1 		abnormal compact bone morphology J:336448
abnormal trabecular bone morphology J:336448
decreased body size J:336448
decreased body weight J:336448
decreased bone mass J:336448
decreased bone mineralization J:336448
decreased bone ossification J:336448
decreased osteoblast cell number J:336448
increased bone marrow adipose tissue amount J:336448
premature death J:336448
Chd7Flo/Chd7+
C3HeB/FeJ-Chd7Flo 		abnormal lateral semicircular canal morphology J:93173
abnormal motor coordination/balance J:93173
abnormal placing response J:93173
abnormal round window morphology J:93173
abnormal stapes footplate morphology J:93173
abnormal stapes morphology J:93173
abnormal stationary movement J:93173
circling J:93173
head bobbing J:93173
impaired righting response J:93173
impaired swimming J:93173
increased cochlear outer hair cell number J:93173
Chd7Flo/Chd7+
involves: C3HeB/FeJ 		abnormal external female genitalia morphology J:104123
clitoris hypoplasia J:104123
dry eyes J:104123
keratoconjunctivitis sicca J:104123
postnatal lethality J:104123
Chd7Gt(RRR136)Byg/Chd7+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cardiac outflow tract development J:154590
abnormal common carotid artery morphology J:154590
abnormal fourth pharyngeal arch artery morphology J:154590
abnormal pharyngeal arch artery morphology J:154590
abnormal sixth pharyngeal arch artery morphology J:154590
aortic arch coarctation J:154590
circling J:154590
ectopic thymus J:154590
small thymus J:154590
thymus hypoplasia J:154590
Chd7Gt(RRR136)Byg/Chd7Gt(RRR136)Byg
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality, complete penetrance J:154590
Chd7Gt(S20-7E1)Sor/Chd7+
129S1.129S4(B6)-Chd7Gt(S20-7E1)Sor 		abnormal estrous cycle J:174086
abnormal hypothalamus physiology J:174086
abnormal neurohypophysis median eminence morphology J:174086
abnormal neuron differentiation J:174086
abnormal neuron physiology J:148116
abnormal olfactory epithelium cilium morphology J:148116
abnormal olfactory epithelium morphology J:148116
abnormal olfactory epithelium physiology J:148116
abnormal olfactory sensory neuron morphology J:148116
abnormal olfactory sensory neuron physiology J:148116
abnormal olfactory system physiology J:174086
abnormal pituitary gland physiology J:174086
abnormal telencephalon morphology J:148116
decreased apoptosis J:174086
decreased body size J:174086
decreased brain size J:148116
decreased cell proliferation J:174086
decreased circulating follicle stimulating hormone level J:174086
decreased circulating luteinizing hormone level J:174086
decreased gonadotropin-releasing hormone neuron number J:174086
decreased olfactory sensory neuron number J:148116
delayed estrous cycle J:174086
delayed sexual maturation J:174086
delayed vaginal opening J:174086
normal endocrine/exocrine gland phenotype J:174086
normal homeostasis/metabolism phenotype J:174086
impaired olfaction J:148116
olfactory bulb hypoplasia J:148116
Chd7Gt(S20-7E1)Sor/Chd7+
B6;129S-Chd7Gt(S20-7E1)Sor/DmmJ 		abnormal semicircular canal morphology J:314662
decreased retina cone cell number J:331474
short retina cone cell outer segment J:331474
short retina rod cell outer segment J:331474
Chd7Gt(S20-7E1)Sor/Chd7+
either: (involves: 129S4/SvJae * C57BL/6J) or (involves: 129S1/SvImJ * 129S4/SvJae C57BL/6J) 		abnormal common crus morphology J:123608
abnormal crista ampullaris morphology J:123608
abnormal crista ampullaris neuroepithelium morphology J:123608
abnormal inner ear vestibular sensory neuron innervation pattern J:123608
abnormal lateral semicircular canal morphology J:123608
abnormal posterior semicircular canal morphology J:123608
abnormal semicircular canal morphology J:123608
abnormal vestibular nerve morphology J:123608
absent posterior semicircular canal J:123608
bidirectional circling J:123608
decreased lateral semicircular canal size J:123608
Chd7Gt(S20-7E1)Sor/Chd7+
involves: 129S1/SvImJ * 129S4/SvJae 		abnormal CNS glial cell morphology J:332873
abnormal vestibulocochlear ganglion morphology J:332873
hypermyelination J:332873
increased or absent threshold for auditory brainstem response J:332873
Chd7Gt(S20-7E1)Sor/Chd7+
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J 		abnormal maternal nurturing J:119812
abnormal semicircular canal morphology J:119812
absent lateral semicircular canal J:119812
absent posterior semicircular canal J:119812
circling J:119812
decreased body weight J:119812
decreased lateral semicircular canal size J:119812
decreased posterior semicircular canal size J:119812
delayed embryo turning J:119812
normal endocrine/exocrine gland phenotype J:119812
head bobbing J:119812
hyperactivity J:119812
postnatal lethality J:119812
reduced female fertility J:119812
Chd7Gt(S20-7E1)Sor/Chd7+
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J * DBA/2J 		abnormal induced morbidity/mortality J:220430
abnormal otic capsule morphology J:220430
abnormal stapes footplate morphology J:220430
abnormal stapes morphology J:220430
absent distortion product otoacoustic emissions J:220430
conductive hearing impairment J:220430
decreased oval window size J:220430
decreased round window size J:220430
decreased susceptibility to noise-induced hearing loss J:220430
impaired hearing J:220430
increased cochlear outer hair cell number J:220430
increased or absent threshold for auditory brainstem response J:220430
sensorineural hearing impairment J:220430
Chd7Gt(S20-7E1)Sor/Chd7+
involves: 129S4/SvJaeSor 		abnormal ear development J:164582
abnormal neuronal precursor cell number J:164582
abnormal neuronal precursor proliferation J:164582
abnormal vestibulocochlear ganglion morphology J:164582
Chd7Gt(S20-7E1)Sor/Chd7+
involves: 129S4/SvJaeSor * C57BL/6J 		abnormal seminiferous tubule morphology J:329885
coloboma J:231044
Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
129S1.129S4(B6)-Chd7Gt(S20-7E1)Sor 		abnormal nasal placode morphology J:174086
abnormal olfactory system physiology J:174086
absent nasal pit J:174086
decreased cell proliferation J:174086
Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J 		abnormal embryonic neuroepithelium morphology J:119812
abnormal hindlimb morphology J:119812
abnormal nasal pit morphology J:119812
abnormal optic eminence morphology J:119812
abnormal otic vesicle development J:119812
abnormal trigeminal ganglion morphology J:119812
decreased embryonic neuroepithelium thickness J:119812
delayed embryo turning J:119812
embryonic lethality during organogenesis, complete penetrance J:119812
Rathke's pouch hypoplasia J:119812
small otic vesicle J:119812
Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor
involves: 129S4/SvJaeSor 		abnormal ear development J:164582
abnormal neuronal precursor cell number J:164582
abnormal neuronal precursor proliferation J:164582
abnormal vestibulocochlear ganglion morphology J:164582
Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm
involves: 129 * C57BL/6 * Swiss Webster 		decreased lateral semicircular canal size J:164582
Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm
Foxg1tm1(cre)Skm/Foxg1+
involves: 129 * C57BL/6 * Swiss Webster 		abnormal cochlea morphology J:164582
abnormal cochlear sensory epithelium morphology J:310063
abnormal crista ampullaris morphology J:164582
abnormal ear development J:164582
abnormal inner ear vestibule morphology J:164582
abnormal neuronal precursor cell number J:164582
abnormal neuronal precursor proliferation J:164582
abnormal suckling behavior J:164582
abnormal vestibulocochlear ganglion morphology J:164582, J:310063
absent lateral semicircular canal J:164582
absent posterior semicircular canal J:164582
absent utricle J:164582
absent vestibular saccule J:164582
decreased cochlea coiling J:164582
decreased superior semicircular canal size J:164582
increased cochlear outer hair cell number J:310063
neonatal lethality, complete penetrance J:164582
ocular hypertelorism J:164582
short snout J:164582
small endolymphatic duct J:164582
Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm
Tg(Pax2-cre)1Akg/0
involves: 129S * C57BL/6 		abnormal cochlea morphology J:310063
absent lateral semicircular canal J:310063
absent superior semicircular canal J:310063
Chd7Gt(S20-7E1)Sor/Chd7tm1.1Dmm
Tg(T-cre)1Lwd/0
involves: 129S * C3H * C57BL/6 		normal hearing/vestibular/ear phenotype J:310063
Chd7Gt(XK403)Byg/Chd7+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) 		abnormal fourth pharyngeal arch artery morphology J:154590
Chd7Gt(XK403)Byg/Chd7+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cardiac outflow tract development J:154590
abnormal cranial nerve morphology J:154590
abnormal fourth pharyngeal arch artery morphology J:154590
abnormal neural crest cell migration J:154590
abnormal pharyngeal arch artery morphology J:154590
abnormal pulmonary trunk morphology J:154590
abnormal sixth pharyngeal arch artery morphology J:154590
abnormal subclavian artery morphology J:154590
abnormal vagus nerve morphology J:154590
aorta coarctation J:154590
circling J:154590
embryonic lethality during organogenesis, incomplete penetrance J:154590
fusion of glossopharyngeal and vagus nerve J:154590
interrupted aortic arch, type b J:154590
postnatal lethality, incomplete penetrance J:154590
Chd7Gt(XK403)Byg/Chd7+
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal cerebellar foliation J:262209
abnormal cerebellar hemisphere morphology J:262209
abnormal cerebellum fissure morphology J:262209
abnormal cerebellum hemisphere lobule morphology J:262209
abnormal cerebellum vermis lobule morphology J:262209
abnormal cerebellum vermis lobule VIII morphology J:262209
abnormal cerebral cortex morphology J:262209
abnormal lobule simplex morphology J:262209
cerebellum hypoplasia J:262209
decreased brain size J:262209
small cerebellum J:262209
Chd7Gt(XK403)Byg/Chd7+
involves: 129P2/OlaHsd * C57BL/6J 		normal nervous system phenotype J:207892
Chd7Gt(XK403)Byg/Chd7+
Mesp1tm2(cre)Ysa/Mesp1+
either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * CD-1) 		abnormal fourth pharyngeal arch artery morphology J:154590
abnormal sixth pharyngeal arch artery morphology J:154590
Chd7Gt(XK403)Byg/Chd7+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
either: (involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J) or (involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1) 		abnormal fourth pharyngeal arch artery morphology J:154590
Chd7Gt(XK403)Byg/Chd7+
Tfap2atm1(cre)Moon/Tfap2a+
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) 		normal embryo phenotype J:154590
Chd7Gt(XK403)Byg/Chd7+
Tg(Tbx1-cre)1Joe/0
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1) 		abnormal fourth pharyngeal arch artery morphology J:154590
abnormal sixth pharyngeal arch artery morphology J:154590
Chd7Gt(XK403)Byg/Chd7Gt(XK403)Byg
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality, complete penetrance J:154590
Chd7Lda/Chd7+
involves: BALB/c * C3H/HeN 		abnormal lateral semicircular canal morphology J:75619
abnormal posterior semicircular canal morphology J:75619
circling J:75619
decreased body size J:75619
head tossing J:75619
Chd7Looper/Chd7+
BALB/c-Chd7Looper 		abnormal glenoid fossa morphology J:252089
abnormal incus long process morphology J:252089
abnormal incus morphology J:252089
abnormal incus short process morphology J:252089
abnormal lateral semicircular canal morphology J:252089
abnormal malleus manubrium morphology J:252089
abnormal middle ear ossicle morphology J:252089
abnormal motor capabilities/coordination/movement J:252089
abnormal oval window morphology J:252089
abnormal posterior semicircular canal morphology J:252089
abnormal stapes footplate morphology J:252089
abnormal stapes morphology J:252089
abnormal superior semicircular canal morphology J:252089
blepharitis J:252089
circling J:252089
conjunctivitis J:252089
decreased body weight J:252089
decreased startle reflex J:252089
eyelid edema J:252089
facial asymmetry J:252089
impaired hearing J:252089
increased locomotor activity J:252089
increased or absent threshold for auditory brainstem response J:252089
narrow eye opening J:252089
otosclerosis J:252089
postnatal growth retardation J:252089
Chd7Looper/Chd7+
involves: BALB/c * C57BL/6 		increased or absent threshold for auditory brainstem response J:252089
Chd7Mt/Chd7+
involves: BALB/c * C3H/HeN 		abnormal lateral semicircular canal morphology J:75619
abnormal posterior semicircular canal morphology J:75619
circling J:75619
decreased body size J:75619
head tossing J:75619
Chd7Obt/Chd7+
involves: BALB/c * C3H/HeN 		abnormal inner ear canal fusion J:75619
abnormal lateral semicircular canal morphology J:75619
abnormal posterior semicircular canal morphology J:75619
circling J:63816
decreased body size J:75619
head tossing J:75619
Chd7Ome/Chd7+
involves: BALB/cByJ * C57BL/6J 		abnormal auditory tube morphology J:187200
abnormal distortion product otoacoustic emission J:187200
abnormal middle ear epithelium morphology J:187200
abnormal stapes footplate morphology J:187200
abnormal stapes head morphology J:187200
absent cochlear microphonics J:187200
circling J:187200
decreased body size J:187200
decreased body weight J:187200
impaired hearing J:187200
impaired swimming J:187200
increased cranium height J:187200
increased middle ear goblet cell number J:187200
increased or absent threshold for auditory brainstem response J:187200
increased periosteum thickness J:187200
increased susceptibility to otitis media J:187200
long snout J:187200
postnatal growth retardation J:187200
reduced male fertility J:187200
small stapes obturator foramen J:187200
Chd7tm1.1Dmm/Chd7+
Foxg1tm1(cre)Skm/Foxg1+
involves: 129 * C57BL/6 * Swiss Webster 		abnormal ear development J:164582
abnormal vestibulocochlear ganglion morphology J:164582
decreased lateral semicircular canal size J:164582
Chd7tm1.1Dmm/Chd7+
Tg(rx3-icre)1Mjam/0
involves: 129S6/SvEvTac 		coloboma J:231044
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * 129S6/SvEvTac 		abnormal lens development J:231044
absent optic cup J:231044
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Olig1tm1(cre)Rth/Olig1+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 		decreased myelin sheath thickness J:234565
decreased oligodendrocyte number J:234565
dysmyelination J:234565
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(Pax2-cre)1Akg/0
involves: 129S1/SvImJ * 129S6/SvEvTac * C57BL/6 		abnormal cochlea morphology J:310063
abnormal cochlear sensory epithelium morphology J:310063
abnormal vestibulocochlear ganglion morphology J:310063
increased cochlear hair cell number J:310063
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(Pax6-cre,GFP)1Pgr/0
involves: 129S6/SvEvTac * FVB 		small lens J:231044
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(Pdgfra-cre/ERT)467Dbe/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal oligodendrocyte apoptosis J:264451
abnormal oligodendrocyte physiology J:234565, J:264451
decreased oligodendrocyte progenitor number J:264451
Chd7tm1.1Dmm/Chd7tm1.1Dmm
Tg(rx3-icre)1Mjam/0
involves: 129S6/SvEvTac 		abnormal eye development J:231044
abnormal optic cup morphology J:231044
absent optic cup J:231044
coloboma J:231044
small lens J:231044
Chd7tm1.2Dmm/Chd7tm1.2Dmm
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal semicircular canal morphology J:164582
circling J:164582
head bobbing J:164582
Chd7tm2a(EUCOMM)Wtsi/Chd7+
129S5;B6N-Chd7tm2a(EUCOMM)Wtsi/Wtsi 		abnormal behavior J:175295
decreased body length J:165965
decreased body weight J:165965
decreased lumbar vertebrae number J:175295
hyperactivity J:175295
Chd7tm2a(EUCOMM)Wtsi/Chd7+
involves: 129S5/SvEvBrd * C57BL/6N 		abnormal circulating enzyme level J:330596
abnormal circulating lipoprotein level J:330596
abnormal corpus callosum morphology J:330596
abnormal hippocampus morphology J:330596
abnormal pupil morphology J:330596
abnormal response to stress-induced hyperthermia J:330596
abnormal retrosplenial granular cortex morphology J:330596
normal behavior/neurological phenotype J:330596
cataract J:330596
decreased body length J:330596
decreased body weight J:330596
decreased bone mineral content J:330596
decreased brain internal capsule size J:330596
decreased circulating alanine transaminase level J:330596
decreased circulating total protein level J:330596
decreased grip strength J:330596
decreased hematocrit J:330596
decreased hemoglobin content J:330596
decreased lean body mass J:330596
decreased leukocyte cell number J:330596
decreased monocyte cell number J:330596
decreased red blood cell distribution width J:330596
increased blood uric acid level J:330596
increased circulating alkaline phosphatase level J:330596
increased habenula size J:330596
increased mammillothalamic tract size J:330596
increased NK T cell number J:330596
Chd7tm2a(EUCOMM)Wtsi/Chd7+
involves: 129S6/SvEvTac * C57BL/6N 		circling J:207089
head bobbing J:207089
Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
involves: 129S5/SvEvBrd * C57BL/6N 		embryonic lethality during organogenesis, incomplete penetrance J:330596
Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
involves: 129S6/SvEvTac * C57BL/6N 		abnormal epigenetic regulation of gene expression J:207089
atrioventricular cushion hypoplasia J:207089
normal cardiovascular system phenotype J:207089
decreased fetal cardiomyocyte proliferation J:207089
embryonic growth arrest J:207089
embryonic lethality during organogenesis, complete penetrance J:207089
increased cardiomyocyte apoptosis J:207089
thin myocardium J:207089
Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
Mesp1tm2(cre)Ysa/Mesp1+
involves: C57BL/6J * C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj 		abnormal atrioventricular cushion morphology J:225736
abnormal cardiac outflow tract development J:225736
abnormal coronary vein morphology J:225736
abnormal fetal cardiomyocyte physiology J:225736
abnormal heart development J:225736
abnormal innervation J:225736
abnormal myocardial trabeculae morphology J:225736
abnormal myocardium compact layer morphology J:225736
abnormal truncus arteriosus septation J:225736
abnormal vein morphology J:225736
aortopulmonary window J:225736
atrioventricular septal defect J:225736
normal cardiovascular system phenotype J:225736
common atrioventricular valve J:225736
congestive heart failure J:225736
double inlet heart left ventricle J:225736
double outlet right ventricle J:225736
edema J:225736
hemorrhage J:225736
interrupted aortic arch, type b J:225736
lethality throughout fetal growth and development, incomplete penetrance J:225736
perinatal lethality, complete penetrance J:225736
thin ventricle myocardium compact layer J:225736
thin ventricular wall J:225736
Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * SJL 		abnormal myocardium compact layer morphology J:225736
atrial septal defect J:225736
atrioventricular septal defect J:225736
normal cardiovascular system phenotype J:225736
edema J:225736
interrupted aortic arch, type b J:225736
preweaning lethality, incomplete penetrance J:225736
ventricular septal defect J:225736
Chd7tm2c(EUCOMM)Wtsi/Chd7+
Tg(Atoh1-cre)1Bfri/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA 		cochlear inner hair cell degeneration J:314588
cochlear outer hair cell degeneration J:314588
increased or absent threshold for auditory brainstem response J:314588
Chd7tm2c(EUCOMM)Wtsi/Chd7+
Tg(Neurod1-cre)RZ24Gsat/0
involves: C57BL/6J * C57BL/6N * FVB/NTac 		abnormal vestibulocochlear ganglion morphology J:314588
increased or absent threshold for auditory brainstem response J:314588
neuron degeneration J:314588
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N 		normal nervous system phenotype J:243947
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * SJL 		abnormal neuron number J:222062
abnormal neuronal stem cell morphology J:222062
decreased neuron number J:222062
decreased neuronal precursor cell number J:222062
increased neuron apoptosis J:222062
increased neuron number J:222062
increased neuronal precursor cell number J:222062
increased neuronal stem cell self-renewal J:222062
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Atoh1-cre)1Bfri/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA 		abnormal cerebellar foliation J:242933
abnormal cerebellar hemisphere morphology J:242933
abnormal cerebellum vermis lobule morphology J:242933
abnormal Purkinje cell morphology J:242933
normal behavior/neurological phenotype J:242933
behavioral developmental delay J:242933
cerebellum hypoplasia J:242933
cerebellum vermis hypoplasia J:242933
cochlear inner hair cell degeneration J:314588
cochlear outer hair cell degeneration J:314588
decreased cerebellar granule cell precursor proliferation J:242933
decreased Purkinje cell number J:242933
impaired coordination J:242933
impaired righting response J:242933
increased cellular sensitivity to oxidative stress J:314588
increased neuron apoptosis J:242933
increased or absent threshold for auditory brainstem response J:314588
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Atoh1-cre)1Bfri/0
involves: C57BL/6 * C57BL/6N * CBA 		abnormal cerebellar foliation J:243947
abnormal cerebellum morphology J:243947
abnormal Purkinje cell morphology J:243947
cerebellum hypoplasia J:243947
decreased cerebellar granule cell number J:243947
increased neuron apoptosis J:243947
premature neuronal precursor differentiation J:243947
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: C57BL/6N 		normal hearing/vestibular/ear phenotype J:314588
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Gdf9-icre)5092Coo/0
involves: C57BL/6 * C57BL/6J * C57BL/6N 		decreased ovary weight J:324165
decreased primary ovarian follicle number J:324165
decreased primordial ovarian follicle number J:324165
decreased secondary ovarian follicle number J:324165
decreased tertiary ovarian follicle number J:324165
impaired ovarian folliculogenesis J:324165
increased atretic ovarian follicle number J:324165
increased granulosa cell apoptosis J:324165
reduced female fertility J:324165
small ovary J:324165
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * SJL 		abnormal cerebellar foliation J:242933
abnormal cerebellum fissure morphology J:242933
abnormal cerebellum vermis lobule IV morphology J:242933
abnormal cerebellum vermis lobule IX morphology J:242933
abnormal cerebellum vermis lobule morphology J:242933
abnormal cerebellum vermis lobule V morphology J:242933
cerebellum hypoplasia J:242933
cerebellum vermis hypoplasia J:242933
decreased body size J:242933
decreased brain size J:242933
ectopic cerebellar granule cells J:242933
postnatal lethality, incomplete penetrance J:242933
small cerebellum J:242933
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * C57BL/6N * SJL 		cerebellum hypoplasia J:243947
perinatal lethality, incomplete penetrance J:243947
Chd7tm2c(EUCOMM)Wtsi/Chd7tm2c(EUCOMM)Wtsi
Tg(Neurod1-cre)RZ24Gsat/0
involves: C57BL/6J * C57BL/6N * FVB/NTac 		abnormal vestibulocochlear ganglion morphology J:314588
increased or absent threshold for auditory brainstem response J:314588
neuron degeneration J:314588
Chd7Todo/Chd7+
involves: BALB/cAnNCrl * C3H/HeN 		abnormal lateral semicircular canal morphology J:75619
abnormal posterior semicircular canal morphology J:75619
circling J:63816
decreased body size J:75619
head tossing J:75619
Chd7Trooper/Chd7+
BALB/c-Chd7Trooper 		abnormal lateral semicircular canal morphology J:262283
abnormal semicircular canal morphology J:262283
abnormal stapes footplate morphology J:262283
blepharitis J:262283
circling J:262283
conjunctivitis J:262283
decreased body weight J:262283
decreased posterior semicircular canal size J:262283
decreased superior semicircular canal size J:262283
head bobbing J:262283
head tilt J:262283
increased or absent threshold for auditory brainstem response J:262283
small stapes J:262283
Chd7Trooper/Chd7Trooper
BALB/c-Chd7Trooper 		lethality, complete penetrance J:262283
Chd7Whi/Chd7+
B6.C3Fe-Chd7Whi 		abnormal lateral semicircular canal morphology J:154590
abnormal posterior semicircular canal morphology J:154590
absent lateral semicircular canal J:154590
Chd7Whi/Chd7+
C3HeB/FeJ-Chd7Whi 		abnormal circulating lipid level J:330596
abnormal circulating lipoprotein level J:330596
abnormal circulating mineral level J:330596
abnormal circulating protein level J:330596
abnormal cochlear hair cell morphology J:99481
abnormal corpus callosum morphology J:330596
abnormal glucose tolerance J:330596
abnormal hippocampus morphology J:330596
abnormal neurohypophysis median eminence morphology J:161880
abnormal olfactory bulb morphology J:161880
abnormal response to stress-induced hyperthermia J:330596
abnormal retrosplenial granular cortex morphology J:330596
abnormal round window morphology J:99481
abnormal stapes morphology J:99481
abnormal superior semicircular canal morphology J:99481
abnormal uterine horn morphology J:161880
abnormal uterus morphology J:161880
absent lateral semicircular canal J:99481
circling J:99481
decreased body fat mass J:330596
decreased body length J:330596
decreased body weight J:161880, J:330596
decreased circulating aspartate transaminase level J:330596
decreased circulating calcium level J:330596
decreased circulating cholesterol level J:330596
decreased circulating free fatty acids level J:330596
decreased circulating glycerol level J:330596
decreased circulating insulin level J:330596
decreased circulating magnesium level J:330596
decreased circulating potassium level J:330596
decreased circulating serum albumin level J:330596
decreased circulating triglyceride level J:330596
decreased gonadotropin-releasing hormone neuron number J:161880
decreased grip strength J:330596
decreased hematocrit J:330596
decreased lateral semicircular canal size J:99481
decreased lean body mass J:330596
decreased monocyte cell number J:330596
decreased percent body fat/body weight J:330596
decreased testis weight J:161880
delayed fertility J:161880
enlarged third ventricle J:330596
head bobbing J:99481, J:330596
normal hearing/vestibular/ear phenotype J:99481
hyperactivity J:99481
impaired olfaction J:161880
increased blood urea nitrogen level J:330596
increased carbon dioxide production J:330596
increased cochlear inner hair cell number J:99481
increased cochlear outer hair cell number J:99481
increased locomotor activity J:330596
increased NK T cell number J:330596
increased oxygen consumption J:330596
increased thermal nociceptive threshold J:330596
olfactory bulb hypoplasia J:161880
small olfactory bulb J:161880
testis hypoplasia J:161880
trunk curl J:330596
normal vision/eye phenotype J:330596
Chd7Whi/Chd7+
involves: C3HeB/FeJ 		abnormal digit development J:104123
abnormal external female genitalia morphology J:104123
abnormal internal nares morphology J:104123
abnormal outer ear morphology J:104123
abnormal palatal shelf fusion at midline J:104123
abnormal secondary palate development J:104123
circling J:104123
cleft secondary palate J:104123
clitoris hypoplasia J:104123
decreased body weight J:104123
decreased palatal rugae number J:104123
decreased total body fat amount J:104123
dry eyes J:104123
edema J:104123
head shaking J:104123
hemorrhage J:104123
keratoconjunctivitis sicca J:104123
postnatal lethality J:104123
ventricular septal defect J:104123
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12/17/2024
MGI 6.24 		The Jackson Laboratory