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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mavs
mitochondrial antiviral signaling protein
MGI:2444773
41 phenotypes from 5 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mavsem1(IMPC)Mbp/Mavsem1(IMPC)Mbp
C57BL/6N-Mavsem1(IMPC)Mbp/MbpMmucd 		decreased bone mineral density J:211773
Mavstm1Aki/Mavstm1Aki
involves: 129P2/OlaHsd * C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:130954
decreased circulating interferon-alpha level J:130954
decreased circulating interferon-beta level J:130954
decreased circulating interferon-gamma level J:130954
decreased circulating interleukin-6 level J:130954
decreased IgG1 level J:130954
decreased IgG2a level J:130954
decreased IgG level J:130954
decreased interferon-beta secretion J:130954
decreased interleukin-12b secretion J:130954
Mavstm1Aki/Mavstm1Aki
involves: 129S/SvEv * C57BL/6 		abnormal circulating interferon level J:162888
abnormal dendritic cell physiology J:162888
abnormal macrophage physiology J:162888
abnormal neuron physiology J:162888
brain inflammation J:162888
CNS inflammation J:162888
decreased CD4-positive, alpha-beta T cell number J:162888
decreased CD8-positive, alpha-beta T cell number J:162888
decreased interferon-beta secretion J:162888
enlarged spleen J:162888
normal immune system phenotype J:162888
increased circulating interferon-gamma level J:162888
increased circulating interleukin-6 level J:162888
increased circulating tumor necrosis factor level J:162888
increased dendritic cell number J:162888
increased IgG2a level J:162888
increased IgG level J:162888
increased IgM level J:162888
increased susceptibility to Flaviviridae infection J:162888
increased susceptibility to Flaviviridae infection induced morbidity/mortality J:162888
neuron degeneration J:162888
Mavstm1Aki/Mavstm1Aki
involves: C57BL/6 		normal immune system phenotype J:132662
Mavstm1Aki/Mavstm1Aki
Not Specified 		abnormal cytokine secretion J:124405
abnormal response to infection J:124405
decreased circulating interleukin-6 level J:124405
decreased interferon-alpha secretion J:124405
decreased interferon-beta secretion J:124405
decreased interleukin-6 secretion J:124405
increased susceptibility to Picornaviridae infection J:124405
Mavstm1Camb/Mavstm1Camb
involves: 129S6/SvEvTac * C57BL/6 		abnormal B cell calcium ion homeostasis J:180356
decreased B cell proliferation J:180356
decreased interleukin-12 secretion J:180356
decreased tumor necrosis factor secretion J:180356
Mavstm1Tsc/Mavstm1Tsc
Not Specified 		decreased interferon-beta secretion J:136289
Mavstm1Zjc/Mavs+
involves: 129/Sv * C57BL/6 		abnormal innate immunity J:110905
increased susceptibility to Riboviria infection J:110905
Mavstm1Zjc/Mavstm1Zjc
B6.Cg-Mavstm1Zjc 		abnormal circulating interferon level J:243916
Mavstm1Zjc/Mavstm1Zjc
involves: 129/Sv * C57BL/6 		abnormal dendritic cell physiology J:110905
abnormal innate immunity J:110905
abnormal macrophage physiology J:110905
increased susceptibility to Riboviria infection J:110905
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory