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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppargc1b
peroxisome proliferative activated receptor, gamma, coactivator 1 beta
MGI:2444934
52 phenotypes from 7 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ppargc1btm1.1Avp/Ppargc1btm1.1Avp
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		abnormal metabolism J:116167
abnormal myocardial fiber mitochondrial morphology J:116167
abnormal skeletal muscle fiber mitochondrial morphology J:116167
abnormal white adipose tissue morphology J:116167
decreased body weight J:116167
decreased circulating cholesterol level J:116167
decreased circulating triglyceride level J:116167
decreased gonadal fat pad weight J:116167
decreased heart rate J:116167
decreased oxygen consumption J:116167
decreased white adipose tissue amount J:116167
hepatic steatosis J:116167
increased liver weight J:116167
increased white fat cell size J:116167
Ppargc1btm1.1Dpk/Ppargc1btm1.1Dpk
involves: 129X1/SvJ * FVB/N 		abnormal brown adipose tissue morphology J:137598
abnormal fat cell morphology J:137598
abnormal muscle physiology J:137598
normal adipose tissue phenotype J:137598
normal cardiovascular system phenotype J:137598
decreased survivor rate J:137598
decreased triglyceride level J:137598
impaired adaptive thermogenesis J:137598
impaired exercise endurance J:137598
normal muscle phenotype J:137598
postnatal lethality J:137598
Ppargc1btm1.1Javi/Ppargc1btm1.1Javi
Tg(Fabp4-cre)1Rev/?
involves: 129P2/OlaHsd * C57BL/6J 		abnormal brown fat cell morphology J:221221
abnormal mitochondrial physiology J:221221
abnormal oxidative phosphorylation J:221221
abnormal respiratory electron transport chain J:221221
abnormal tricarboxylic acid cycle J:221221
normal adipose tissue phenotype J:221221
normal behavior/neurological phenotype J:221221
decreased brown fat lipid droplet number J:221221
normal growth/size/body region phenotype J:221221
normal homeostasis/metabolism phenotype J:221221
increased brown adipose tissue amount J:221221
increased brown fat cell lipid droplet size J:221221
Ppargc1btm1.1Rev/Ppargc1btm1.1Rev
involves: 129 * C57BL/6J 		decreased circulating free fatty acids level J:120079
decreased circulating triglyceride level J:120079
decreased locomotor activity J:120079
normal homeostasis/metabolism phenotype J:120079
impaired adaptive thermogenesis J:120079
increased circulating free fatty acids level J:120079
increased circulating triglyceride level J:120079
increased liver triglyceride level J:120079
increased liver weight J:120079
macrovesicular hepatic steatosis J:120079
postnatal lethality, incomplete penetrance J:120079
Ppargc1btm1.2Rev/Ppargc1btm1.2Rev
Tg(Tek-cre)1Ywa/0
involves: 129/Sv * C57BL/6 * C57BL/6J * SJL 		abnormal osteoclast differentiation J:160910
decreased bone resorption J:160910
Ppargc1btm1Lowl/Ppargc1btm1Lowl
involves: C57BL/6 		abnormal mitochondrial morphology J:129775
abnormal mitochondrial physiology J:129775
increased liver triglyceride level J:129775
insulin resistance J:129775
Tg(Ckm-Ppargc1b)T37Brsp/0
FVB-Tg(Ckm-Ppargc1b)T37Brsp 		abnormal mitochondrial morphology J:118258
abnormal muscle physiology J:118258
abnormal skeletal muscle fiber type ratio J:118258
abnormal skeletal muscle morphology J:118258
decreased skeletal muscle fiber size J:118258
enhanced exercise endurance J:118258
skeletal muscle hypoplasia J:118258
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory