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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Malt1
MALT1 paracaspase
MGI:2445027
14 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Malt1m1Btlr/Malt1+
C57BL/6J-Malt1m1Btlr 		impaired humoral immune response J:221474
Malt1m1Btlr/Malt1m1Btlr
C57BL/6J-Malt1m1Btlr 		impaired humoral immune response J:221474
Malt1m2Btlr/Malt1+
C57BL/6J-Malt1m2Btlr 		decreased IgM level J:224671
impaired humoral immune response J:224671
Malt1m2Btlr/Malt1m2Btlr
C57BL/6J-Malt1m2Btlr 		decreased IgG level J:224671
decreased IgM level J:224671
impaired humoral immune response J:224671
Malt1m3Btlr/Malt1+
C57BL/6J-Malt1m3Btlr 		decreased IgM level J:224672
impaired humoral immune response J:224672
Malt1m3Btlr/Malt1m3Btlr
C57BL/6J-Malt1m3Btlr 		decreased IgG level J:224672
decreased IgM level J:224672
impaired humoral immune response J:224672
Malt1tm1Mak/Malt1tm1Mak
involves: 129P2/OlaHsd 		abnormal dendritic cell physiology J:111706
decreased IgG level J:109545
decreased IgM level J:109545
decreased T cell proliferation J:109545
Malt1tm1Vmd/Malt1tm1Vmd
involves: C57BL/6N 		abnormal B cell differentiation J:86770
abnormal double-negative T cell morphology J:86770
abnormal immune system morphology J:86770
abnormal spleen marginal zone morphology J:86770
abnormal T cell differentiation J:86770
abnormal T cell proliferation J:86770
absent B-1a cells J:86770
decreased immunoglobulin level J:86770
decreased interleukin-2 secretion J:86770
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory