Sik2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sik2
salt inducible kinase 2
MGI:2445031

19 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sik2^em1(IMPC)Mbp/Sik2^em1(IMPC)Mbp C57BL/6N-Sik2^em1(IMPC)Mbp/Ucd	enlarged heart	J:211773
Sik2^tm1Htake/Sik2^tm1Htake C57BL/6-Sik2^tm1Htake	darkened coat color	J:215877
Sik2^tm1Lex/Sik2^tm1Lex involves: 129S/SvEvBrd	abnormal fat cell differentiation	J:229999
	decreased adipocyte glucose uptake	J:229999
	decreased circulating adiponectin level	J:229999
	decreased energy expenditure	J:229999
	decreased fatty acid oxidation	J:229999
	decreased food intake	J:229999
	decreased muscle cell glucose uptake	J:229999
	decreased respiratory quotient	J:229999
	enhanced lipolysis	J:229999
	impaired glucose tolerance	J:229999
	increased circulating glucose level	J:229999
	increased circulating insulin level	J:229999
	increased circulating triglyceride level	J:229999
	increased inflammatory response	J:229999
	increased locomotor activity	J:229999
	increased white fat cell size	J:229999
	insulin resistance	J:229999

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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