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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Senp1
SUMO1/sentrin specific peptidase 1
MGI:2445054
57 phenotypes from 7 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Senp1em1(IMPC)H/Senp1em1(IMPC)H
C57BL/6NTac-Senp1em1(IMPC)H/H 		preweaning lethality, complete penetrance J:211773
Senp1Gt(OST215108)Lex/Senp1+
B6;129S5-Senp1Gt(OST215108)Lex/Orl 		enhanced coordination J:82809
Senp1Gt(OST215108)Lex/Senp1Gt(OST215108)Lex
B6;129S5-Senp1Gt(OST215108)Lex/Orl 		prenatal lethality, complete penetrance J:82809
Senp1Gt(XG001)Byg/Senp1Gt(XG001)Byg
involves: 129P2/OlaHsd 		abnormal erythropoiesis J:141453
anemia J:141453
decreased erythrocyte cell number J:141453
decreased erythroid progenitor cell number J:141453
decreased fetal size J:141453
normal hematopoietic system phenotype J:141453
lethality throughout fetal growth and development, incomplete penetrance J:141453
pallor J:141453
small liver J:141453
Senp1m1Mku/Senp1m1Mku
involves: 129 		abnormal cell death J:99175
abnormal placental labyrinth vasculature morphology J:99175
lethality throughout fetal growth and development, complete penetrance J:99175
prenatal lethality J:88845
Senp1tm1.1Eyeh/Senp1+
Tg(Pdx1-cre)6Tuv/0
involves: C57BL/6 		impaired glucose tolerance J:226392
Senp1tm1.1Eyeh/Senp1tm1.1Eyeh
Not Specified 		abnormal pancreatic beta cell physiology J:226392
decreased insulin secretion J:226392
Senp1tm1.1Eyeh/Senp1tm1.1Eyeh
Tg(Pdx1-cre)6Tuv/0
involves: C57BL/6 		abnormal pancreatic beta cell physiology J:226392
decreased circulating insulin level J:226392
decreased insulin secretion J:226392
normal growth/size/body region phenotype J:226392
impaired ability to fire action potentials J:226392
impaired glucose tolerance J:226392
Senp1tm1.1Eyeh/Senp1tm1.1Eyeh
Tg(Pdx1-cre/Esr1*)#Dam/0
involves: C57BL/6 		decreased insulin secretion J:226392
impaired glucose tolerance J:226392
Senp1tm1.1Wami/Senp1tm1.1Wami
involves: 129 * C57BL/6 		abnormal erythropoiesis J:163428
abnormal granulocyte differentiation J:163428
abnormal hemoglobin content J:163428
abnormal liver physiology J:163428
abnormal megakaryocyte progenitor cell morphology J:163428
abnormal monocyte differentiation J:163428
abnormal vascular development J:163428
abnormal vitelline vasculature morphology J:163428
anemia J:163428
decreased erythroid progenitor cell number J:163428
decreased liver weight J:163428
lethality throughout fetal growth and development, complete penetrance J:163428
pale liver J:163428
postnatal lethality, complete penetrance J:163428
prenatal lethality, complete penetrance J:150995
small liver J:163428
Senp1tm1Wami/Senp1tm1Wami
Tg(Adipoq-cre)1Evdr/0
B6.Cg-Senp1tm1Wami Tg(Adipoq-cre)1Evdr 		abnormal pancreatic islet morphology J:228009
decreased body weight J:228009
decreased insulin secretion J:228009
normal homeostasis/metabolism phenotype J:228009
hyperglycemia J:228009
increased pancreatic beta cell apoptosis J:228009
Senp1tm1Wami/Senp1tm1Wami
Tg(Cdh5-cre)7Mlia/0
involves: 129 * C57BL/6 * FVB/N 		normal homeostasis/metabolism phenotype J:228009
Senp1tm1Wami/Senp1tm1Wami
Tg(Fabp4-cre)#Abel/0
B6.Cg-Senp1tm1Wami Tg(Fabp4-cre)#Abel 		abnormal chemokine level J:228009
abnormal circulating cytokine level J:228009
abnormal cytokine level J:228009
abnormal fat cell morphology J:228009
abnormal pancreatic islet morphology J:228009
decreased body weight J:228009
decreased circulating cholesterol level J:228009
decreased circulating insulin level J:228009
decreased circulating triglyceride level J:228009
decreased fat cell size J:228009
decreased insulin secretion J:228009
decreased total fat pad weight J:228009
hyperglycemia J:228009
impaired glucose tolerance J:228009
increased anti-insulin autoantibody level J:228009
increased circulating C-reactive protein level J:228009
increased circulating interleukin-1 beta level J:228009
increased circulating interleukin-6 level J:228009
increased circulating ketone body level J:228009
increased circulating tumor necrosis factor level J:228009
increased fluid intake J:228009
increased susceptibility to autoimmune diabetes J:228009
insulin resistance J:228009
myocarditis J:228009
pancreas inflammation J:228009
Senp1tm1Wami/Senp1tm1Wami
Tg(Pdgfra-cre)1Clc/0
B6.Cg-Senp1tm1Wami Tg(Pdgfra-cre)1Clc 		abnormal pancreatic beta cell physiology J:228009
abnormal pancreatic islet cell apoptosis J:228009
abnormal pancreatic islet morphology J:228009
decreased body weight J:228009
hyperglycemia J:228009
Senp1tm1Wami/Senp1tm1Wami
Tg(Tagln-cre)1Jjl/0
involves: 129 * C57BL/6 * FVB/N 		normal homeostasis/metabolism phenotype J:228009
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory