Lacc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lacc1
laccase domain containing 1
MGI:2445077

12 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lacc1^em1Arkr/Lacc1^em1Arkr C57BL/6NTac-Lacc1^em1Arkr	abnormal macrophage physiology	J:244365
	abnormal redox activity	J:244365
	decreased circulating interleukin-1 beta level	J:244365
	decreased susceptibility to endotoxin shock	J:244365
Lacc1^em2Arkr/Lacc1^em2Arkr C57BL/6NTac-Lacc1^em2Arkr	abnormal macrophage physiology	J:244365
	abnormal redox activity	J:244365
	decreased circulating interleukin-1 beta level	J:244365
	decreased susceptibility to endotoxin shock	J:244365
Lacc1^em3Arkr/Lacc1^em3Arkr C57BL/6NTac-Lacc1^em3Arkr	abnormal macrophage physiology	J:244365
	abnormal redox activity	J:244365
	increased circulating interleukin-1 beta level	J:244365
	increased susceptibility to endotoxin shock	J:244365
Lacc1^em4Arkr/Lacc1^em4Arkr C57BL/6NTac-Lacc1^em4Arkr	abnormal macrophage physiology	J:244365
	abnormal redox activity	J:244365
	increased circulating interleukin-1 beta level	J:244365
	increased susceptibility to endotoxin shock	J:244365
Lacc1^{tm1a(KOMP)Wtsi}/Lacc1^{tm1a(KOMP)Wtsi} involves: C57BL/6N * C57BL/6NTac	abnormal cellular respiration	J:244365
	abnormal macrophage morphology	J:244365
	abnormal macrophage physiology	J:244365
	abnormal oxidative phosphorylation	J:244365
	abnormal redox activity	J:244365
	decreased circulating tumor necrosis factor level	J:244365
	decreased fatty acids level	J:244365
	decreased interleukin-1 beta secretion	J:244365
	increased circulating interleukin-1 beta level	J:244365
	increased susceptibility to endotoxin shock	J:244365

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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