Timd4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Timd4
T cell immunoglobulin and mucin domain containing 4
MGI:2445125

22 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Timd4^tm1Kuch/Timd4^tm1Kuch C57BL/6-Timd4^tm1Kuch	abnormal B cell physiology	J:160747
	abnormal macrophage physiology	J:160747
	increased anti-double stranded DNA antibody level	J:160747
	increased IgA level	J:160747
	increased IgG2a level	J:160747
	increased IgG2b level	J:160747
	increased interferon-gamma secretion	J:160747
	increased interleukin-17 secretion	J:160747
	increased splenocyte proliferation	J:160747
Timd4^tm1Kuch/Timd4^tm1Kuch involves: C57BL/6	abnormal circulating chemokine level	J:235399
	decreased circulating interleukin-10 level	J:235399
	increased anti-double stranded DNA antibody level	J:235399
	increased circulating creatinine level	J:235399
	increased circulating interleukin-1 beta level	J:235399
	increased circulating interleukin-6 level	J:235399
	increased circulating interleukin-12b level	J:235399
	increased susceptibility to systemic lupus erythematosus	J:235399
Timd4^tm1Osa/Timd4^tm1Osa involves: C57BL/6	normal immune system phenotype	J:187181
Timd4^tm1Osa/Timd4^tm1Osa involves: C57BL/6	impaired macrophage phagocytosis	J:187181
Timd4^tm1Wouy/Timd4^tm1Wouy involves: 129	abnormal macrophage physiology	J:160304
	decreased tumor necrosis factor secretion	J:160304
	impaired macrophage phagocytosis	J:160304
	increased IgG2a level	J:160304
	increased leukocyte cell number	J:160304
	increased lymphocyte cell number	J:160304
	increased tumor necrosis factor secretion	J:160304

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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