Plac8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plac8
placenta-specific 8
MGI:2445289

19 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plac8^{tm1b(EUCOMM)Hmgu}/Plac8^{tm1b(EUCOMM)Hmgu} C57BL/6N-Plac8^{tm1b(EUCOMM)Hmgu}/Ieg	abnormal coat appearance	J:211773
	abnormal lens morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	persistence of hyaloid vascular system	J:211773
Plac8^tm1Bhk/Plac8⁺ involves: 129S6/SvEvTac * C57BL/6	decreased brown fat lipid droplet number	J:179647
	increased body fat mass	J:179647
	increased body weight	J:179647
	increased brown fat cell lipid droplet size	J:179647
	whitened brown adipose tissue morphology	J:179647
Plac8^tm1Bhk/Plac8^tm1Bhk 129S/SvEv-Plac8^tm1Bhk	abnormal neutrophil physiology	J:145277
	increased leukocyte cell number	J:145277
	increased neutrophil cell number	J:145277
	increased susceptibility to bacterial infection	J:145277
	increased vascular permeability	J:145277
Plac8^tm1Bhk/Plac8^tm1Bhk involves: 129S6/SvEvTac * C57BL/6	abnormal neutrophil physiology	J:145277
	decreased body temperature	J:179647
	decreased brown fat lipid droplet number	J:179647
	impaired adaptive thermogenesis	J:179647
	increased body fat mass	J:179647
	increased body weight	J:179647
	increased brown fat cell lipid droplet size	J:179647
	whitened brown adipose tissue morphology	J:179647

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24