Eif2b5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
MGI:2446176

36 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Eif2b5^tm1.1Sidr/Eif2b5^tm1.1Sidr B6(Cg)-Eif2b5^tm1.1Sidr	abnormal nervous system physiology	J:278928
	decreased grip strength	J:278928
	demyelination	J:278928
	gliosis	J:278928
	impaired coordination	J:278928
	slow postnatal weight gain	J:278928
Eif2b5^tm1.1Vdk/Eif2b5^tm1.1Vdk involves: C57BL/6 * C57BL/6J	abnormal astrocyte morphology	J:234659
	abnormal axon morphology	J:234659
	abnormal cerebellum white matter morphology	J:234659
	abnormal forebrain morphology	J:234659
	abnormal locomotor activation	J:234659
	abnormal myelination	J:234659
	abnormal retina inner nuclear layer morphology	J:234659
	abnormal retina morphology	J:234659
	abnormal retina outer nuclear layer morphology	J:234659
	ataxia	J:234659
	brain vacuoles	J:234659
	decreased body weight	J:234659
	decreased grip strength	J:234659
	decreased oligodendrocyte number	J:234659
	ectopic Bergmann glia cells	J:234659
	impaired coordination	J:234659
	increased hyaluronic acid level	J:234659
	premature death	J:234659
	sporadic seizures	J:234659
	thin retina inner plexiform layer	J:234659
Eif2b5^{tm1a(EUCOMM)Wtsi}/Eif2b5⁺ C57BL/6N-Eif2b5^{tm1a(EUCOMM)Wtsi}/Ics	decreased circulating glucose level	J:165965
	decreased heart weight	J:165965
	decreased mean corpuscular hemoglobin concentration	J:165965
	decreased mean corpuscular volume	J:165965
Eif2b5^tm1Itl/Eif2b5^tm1Itl B.129S-Eif2b5^tm1Itl	impaired coordination	J:179801
Eif2b5^tm1Itl/Eif2b5^tm1Itl involves: 129S/SvEv	abnormal astrocyte morphology	J:192103
	abnormal astrocyte physiology	J:192103
	abnormal microglial cell physiology	J:192103
Eif2b5^tm1Itl/Eif2b5^tm1Itl involves: 129S/SvEv * C57BL * Swiss Webster	abnormal astrocyte morphology	J:179801
	abnormal axon morphology	J:179801
	abnormal brain internal capsule morphology	J:179801
	abnormal brain white matter morphology	J:179801
	abnormal physiological response to xenobiotic	J:179801
	decreased percent body fat/body weight	J:179801
	demyelination	J:179801
	increased oligodendrocyte number	J:179801
Eif2b5^tm2.1Sidr/Eif2b5^tm2.1Sidr B6(Cg)-Eif2b5^tm2.1Sidr	abnormal nervous system physiology	J:278928
Eif2b5^tm2.1Sidr/Eif2b5^tm2.1Sidr B6(Cg)-Eif2b5^tm2.1Sidr	normal mortality/aging	J:278928

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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