Setd1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Setd1a
SET domain containing 1A
MGI:2446244

24 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Setd1a^em1Yzhg/Setd1a⁺ B6.Cg-Setd1a^em1Yzhg	abnormal dendrite arborization pattern	J:328716
	abnormal sucrose solution preference	J:328716
	abnormal synaptic vesicle exocytosis	J:328716
	anhedonia	J:328716
	decreased dendritic spine density	J:328716
	decreased prepulse inhibition	J:328716
	increased freezing behavior	J:328716
	reduced sensorimotor gating	J:328716
Setd1a^tm1.1Afst/Setd1a^tm1.1Afst Tg(Gdf9-icre)5092Coo/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal reproductive system phenotype	J:207420
Setd1a^tm1.1Afst/Setd1a^tm1.2Afst Tg(Gdf9-icre)5092Coo/0 involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	embryonic growth retardation	J:208420
Setd1a^tm1.2Afst/Setd1a^tm1.2Afst involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:208420
	failure to gastrulate	J:208420
Setd1a^{tm1a(EUCOMM)Wtsi}/Setd1a⁺ C57BL/6N-Setd1a^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased circulating alanine transaminase level	J:175295
	decreased circulating alkaline phosphatase level	J:175295
	decreased circulating cholesterol level	J:175295
	decreased circulating HDL cholesterol level	J:175295
	decreased circulating LDL cholesterol level	J:175295
	decreased leukocyte cell number	J:175295
	decreased rib number	J:175295
	decreased total body fat amount	J:175295
	increased bone mineral density	J:175295
Setd1a^tm1Afst/Setd1a^tm1Afst involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cell physiology	J:208420
	abnormal DNA methylation	J:208420
	normal cellular phenotype	J:208420
	embryonic lethality between implantation and somite formation, complete penetrance	J:208420
	failure to gastrulate	J:208420

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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