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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Megf8
multiple EGF-like-domains 8
MGI:2446294
76 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Megf8b2b288Clo/Megf8b2b288Clo
C57BL/6J-Megf8b2b288Clo 		anophthalmia J:175213
cleft palate J:175213
complete atrioventricular septal defect J:175213
d-loop transposition of the great arteries J:175213
dextrocardia J:175213
double outlet right ventricle, ventricular defect committed to aorta J:175213
heterotaxia J:175213
micrognathia J:175213
short snout J:175213
Megf8b2b1702.2Clo/Megf8b2b1702.2Clo
C57BL/6J-Megf8b2b1702.2Clo 		anophthalmia J:175213
atrioventricular septal defect J:175213
cleft palate J:175213
coronary fistula J:175213
decreased body size J:175213
dextrocardia J:175213
double outlet right ventricle J:175213
double outlet right ventricle, Taussig bing type J:175213
double outlet right ventricle, ventricular defect committed to aorta J:175213
heterotaxia J:175213
micrognathia J:175213
microphthalmia J:175213
muscular ventricular septal defect J:175213
omphalocele J:175213
petechiae J:175213
right pulmonary isomerism J:175213
right-sided stomach J:175213
short snout J:175213
spleen hypoplasia J:175213
thymus hypoplasia J:175213
transposition of great arteries J:175213
Megf8Gt(G037A09)Wrst/Megf8Gt(G037A09)Wrst
involves: 129S6/SvEvTac * C57BL/6J 		abnormal atrioventricular valve morphology J:206541
abnormal autopod morphology J:206541
abnormal cardiac outflow tract development J:206541
abnormal direction of embryo turning J:206541
abnormal direction of heart looping J:206541
abnormal heart atrium morphology J:206541
abnormal mitral valve morphology J:206541
abnormal thoracic cage morphology J:206541
abnormal tricuspid valve morphology J:206541
atrial septal defect J:206541
normal cardiovascular system phenotype J:206541
delayed bone ossification J:206541
edema J:206541
heart right ventricle outflow tract stenosis J:206541
lethality throughout fetal growth and development, complete penetrance J:206541
preaxial polydactyly J:206541
split sternum J:206541
ventricular septal defect J:206541
Megf8Gt(G037A09)Wrst/Megf8m687Ddg
involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J 		abnormal axon fasciculation J:206541
abnormal ophthalmic nerve morphology J:206541
abnormal trigeminal nerve morphology J:206541
Megf8hlb611/Megf8hlb611
involves: C57BL/6J 		abdominal situs abnormality J:311933
abnormal cardiac outflow tract development J:146805
abnormal direction of embryo turning J:146805
abnormal direction of heart looping J:146805
abnormal heart position or orientation J:311933
abnormal heart septum morphology J:311933
absent spleen J:146805
accessory spleen J:146805
anomalous pulmonary venous connection J:146805
atrioventricular septal defect J:311933
dextrocardia J:146805, J:311933
normal embryo phenotype J:146805
normal hematopoietic system phenotype J:146805
heterotaxia J:146805, J:311933
lung situs inversus J:311933
mesocardia J:146805, J:311933
preaxial polydactyly J:311933
right pulmonary isomerism J:146805
right-sided stomach J:146805
situs inversus J:311933
transposition of great arteries J:146805, J:311933
ventricular septal defect J:311933
Megf8hlb611/Megf8hlb611
involves: C57BL/6J * C3H/HeJ 		abnormal heart and great artery attachment J:146957
abnormal heart left ventricle morphology J:146957
abnormal liver morphology J:146957
abnormal stomach position or orientation J:146957
abnormal ureter morphology J:146957
absent coronary sinus J:146957
absent spleen J:146957
accessory spleen J:146957
anomalous pulmonary venous connection J:146957
atrial septal defect J:146957
complete atrioventricular septal defect J:146957
dextrocardia J:146957
heterotaxia J:146957
mesocardia J:146957
polydactyly J:146957
renal hypoplasia J:146957
right aortic arch J:146957
right atrial isomerism J:146957
right pulmonary isomerism J:146957
trabecula carnea hypoplasia J:146957
transposition of great arteries J:146957
ventricular septal defect J:146957
Megf8m687Ddg/Megf8m687Ddg
involves: C3H/He * C57BL/6 		abnormal axon fasciculation J:159834, J:206541
abnormal nervous system morphology J:159834
abnormal ophthalmic nerve morphology J:159834, J:206541
abnormal spinal nerve morphology J:159834
abnormal trigeminal nerve morphology J:206541
Megf8tm1.1Ddg/Megf8tm1.1Ddg
involves: 129S6/SvEvTac * BALB/cJ 		abnormal autopod morphology J:206541
abnormal axon extension J:206541
abnormal axon fasciculation J:206541
abnormal cardiac outflow tract development J:206541
abnormal direction of embryo turning J:206541
abnormal direction of heart looping J:206541
abnormal glossopharyngeal nerve morphology J:206541
abnormal heart atrium morphology J:206541
abnormal maxillary nerve morphology J:206541
abnormal mitral valve morphology J:206541
abnormal ophthalmic nerve morphology J:206541
abnormal spinal nerve morphology J:206541
abnormal thoracic cage morphology J:206541
abnormal tricuspid valve morphology J:206541
abnormal trigeminal nerve morphology J:206541
abnormal vagus nerve morphology J:206541
atrial septal defect J:206541
normal cardiovascular system phenotype J:206541
delayed bone ossification J:206541
delayed limb development J:206541
edema J:206541
exencephaly J:206541
heart right ventricle outflow tract stenosis J:206541
lethality throughout fetal growth and development, complete penetrance J:206541
preaxial polydactyly J:206541
split sternum J:206541
ventricular septal defect J:206541
Megf8tm1.2Ddg/Megf8tm1.2Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal axon fasciculation J:206541
abnormal ophthalmic nerve morphology J:206541
normal limbs/digits/tail phenotype J:206541
normal nervous system phenotype J:206541
Megf8tm1.2Ddg/Megf8tm1.2Ddg
Mesp1tm2(cre)Ysa/Mesp1+
involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj 		normal cardiovascular system phenotype J:206541
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory