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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ago2
argonaute RISC catalytic subunit 2
MGI:2446632
30 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ago2Gt(XE344)Byg/Ago2Gt(XE344)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal embryonic tissue morphology J:121791
normal cellular phenotype J:121791
embryonic growth arrest J:121791
embryonic lethality between implantation and somite formation, complete penetrance J:121791
Ago2Gt(XE344)Byg/Ago2tm2Ghan
involves: 129P2/OlaHsd 		placental labyrinth hypoplasia J:161968
small placenta J:161968
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * CBA/J 		abnormal pancreatic beta cell morphology J:210552
decreased pancreatic beta cell mass J:210552
decreased pancreatic beta cell number J:210552
decreased pancreatic beta cell proliferation J:210552
normal endocrine/exocrine gland phenotype J:210552
normal homeostasis/metabolism phenotype J:210552
improved glucose tolerance J:210552
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(KRT14-cre)1Efu/0
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:183622
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA 		abnormal erythrocyte morphology J:165967
abnormal erythrocyte physiology J:165967
abnormal erythropoiesis J:165967
anemia J:165967
decreased erythrocyte cell number J:165967
decreased hematocrit J:165967
decreased hemoglobin content J:165967
decreased mean corpuscular hemoglobin J:165967
decreased mean corpuscular volume J:165967
enlarged spleen J:165967
increased number of Heinz bodies J:165967
increased red blood cell distribution width J:165967
reticulocytosis J:165967
Ago2tm3.1Ghan/Ago2tm3.1Ghan
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA * Swiss Webster 		abnormal proerythroblast morphology J:161968
decreased erythrocyte cell number J:161968
neonatal lethality, complete penetrance J:161968
pallor J:161968
Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh/Gt(ROSA)26Sortm1(CAG-GFP/Eif2c2)Zjh
involves: C57BL/6 * NZB 		no abnormal phenotype detected J:179351
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory