Disc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Disc1
disrupted in schizophrenia 1
MGI:2447658

57 phenotypes from 9 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Disc1^del/Disc1^del B6.129S6-Disc1^del	abnormal learning/memory/conditioning	J:107244
Disc1^em1(IMPC)Mbp/Disc1^em1(IMPC)Mbp C57BL/6N-Disc1^em1(IMPC)Mbp/MbpMmucd	abnormal heart morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal vitreous body morphology	J:211773
	cataract	J:211773
	enlarged heart	J:211773
	eye hemorrhage	J:211773
	hyperactivity	J:211773
	increased prepulse inhibition	J:211773
	small kidney	J:211773
Disc1^m1H/Disc1^m1H B6N.C(C3H)-Disc1^m1H	abnormal social investigation	J:229661
	normal behavior/neurological phenotype	J:229661
	decreased exploration in new environment	J:229661
	decreased vertical activity	J:229661
	impaired passive avoidance behavior	J:229661
	increased anxiety-related response	J:229661
	increased locomotor activity	J:229661
	increased thigmotaxis	J:229661
Disc1^Rgsc1390/Disc1⁺ B6.Cg-Disc1^Rgsc1390	abnormal entorhinal cortex morphology	J:120634
	abnormal latent inhibition of conditioning behavior	J:120634
	abnormal prepulse inhibition	J:120634
	normal behavior/neurological phenotype	J:120634
	decreased brain size	J:120634
	decreased startle reflex	J:120634
	small cerebellum	J:120634
	small thalamus	J:120634
	thin cerebral cortex	J:120634
Disc1^Rgsc1390/Disc1^Rgsc1390 B6.Cg-Disc1^Rgsc1390	abnormal entorhinal cortex morphology	J:120634
	abnormal latent inhibition of conditioning behavior	J:120634
	abnormal prepulse inhibition	J:120634
	abnormal spatial learning	J:120634
	abnormal spatial working memory	J:120634
	normal behavior/neurological phenotype	J:120634
	decreased brain size	J:120634
	decreased startle reflex	J:120634
	increased exploration in new environment	J:120634
	small cerebellum	J:120634
	small thalamus	J:120634
	thin cerebral cortex	J:120634
Disc1^Rgsc1390/Disc1^Rgsc1393 B6.Cg-Disc1^Rgsc1390/Disc1^Rgsc1393	abnormal prepulse inhibition	J:120634
	decreased startle reflex	J:120634
Disc1^Rgsc1393/Disc1⁺ B6.Cg-Disc1^Rgsc1393	abnormal entorhinal cortex morphology	J:120634
	abnormal social/conspecific interaction behavior	J:120634
	decreased brain size	J:120634
	normal nervous system phenotype	J:120634
	small cerebellum	J:120634
	small thalamus	J:120634
	thin cerebral cortex	J:120634
Disc1^Rgsc1393/Disc1^Rgsc1393 B6.Cg-Disc1^Rgsc1393	abnormal entorhinal cortex morphology	J:120634
	abnormal latent inhibition of conditioning behavior	J:120634
	abnormal liquid preference	J:120634
	abnormal prepulse inhibition	J:120634
	abnormal social/conspecific interaction behavior	J:120634
	abnormal spatial working memory	J:120634
	normal behavior/neurological phenotype	J:120634
	behavioral despair	J:120634
	decreased brain size	J:120634
	small cerebellum	J:120634
	small thalamus	J:120634
	thin cerebral cortex	J:120634
Disc1^tm1Kara/Disc1⁺ B6.129S6-Disc1^tm1Kara	abnormal learning/memory/conditioning	J:107244
Disc1^tm1Kara/Disc1^tm1Kara B6.129S6-Disc1^tm1Kara	abnormal learning/memory/conditioning	J:107244
Disc1^tm1Kozo/Disc1^tm1Kozo B6JJmsSlc.Cg-Disc1^tm1Kozo	abnormal impulsive behavior control	J:177560
	abnormal long-term potentiation	J:177560
	abnormal response to novel object	J:177560
	abnormal social investigation	J:177560
	abnormal synaptic depression	J:177560
	normal behavior/neurological phenotype	J:177560
	decreased anxiety-related response	J:177560
	decreased prepulse inhibition	J:177560
	decreased serotonin level	J:177560
	enhanced contextual conditioning behavior	J:177560
	increased locomotor activity	J:177560
	induced hyperactivity	J:177560
	normal nervous system phenotype	J:177560
	reduced long-term potentiation	J:177560
Tg(Camk2a-ESR1/Disc1)2698.1Sva/0 involves: C57BL/6 C57BL/6NTac	abnormal CNS synaptic transmission	J:127235
	abnormal dendrite morphology	J:127235
	abnormal neuron morphology	J:127235
	abnormal social investigation	J:127235
	abnormal spatial working memory	J:127235
	behavioral despair	J:127235
	social withdrawal	J:127235
Tg(Disc1/EGFP)M19Sshe/0 involves: C57BL/6JCrl * CBA/CaCrl	abnormal axon extension	J:143557
	abnormal brain interneuron morphology	J:143557
	abnormal latent inhibition of conditioning behavior	J:143557
	abnormal neurite morphology	J:143557
	abnormal neuron proliferation	J:143557
	behavioral despair	J:143557
	decreased brain size	J:143557
	decreased corpus callosum size	J:143557
	decreased neuron number	J:143557
	decreased vocalization	J:143557
	dilated lateral ventricle	J:143557
	enlarged lateral ventricles	J:143557
	thin cerebral cortex	J:143557

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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