Fancd2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fancd2
Fanconi anemia, complementation group D2
MGI:2448480

48 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fancd2^{em1(IMPC)Hmgu}/Fancd2⁺ C57BL/6NCrl-Fancd2^{em1(IMPC)Hmgu}/Ieg	abnormal retina blood vessel morphology	J:211773
	decreased locomotor activity	J:211773
	increased circulating iron level	J:211773
	persistence of hyaloid vascular system	J:211773
	small kidney	J:211773
Fancd2^{em1(IMPC)Hmgu}/Fancd2^{em1(IMPC)Hmgu} C57BL/6NCrl-Fancd2^{em1(IMPC)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773
Fancd2^em1Tzh/Fancd2^em1Tzh C57BL/6-Fancd2^em1Tzh	abnormal bone marrow cell morphology/development	J:284566
	abnormal erythropoiesis	J:284566
	abnormal hematopoietic stem cell physiology	J:284566
	abnormal lens development	J:284566
	abnormal ovarian follicle morphology	J:284566
	abnormal retina development	J:284566
	abnormal testis morphology	J:284566
	anemia	J:284566
	aphakia	J:284566
	azoospermia	J:284566
	decreased body size	J:284566
	decreased erythroblast number	J:284566
	decreased erythrocyte cell number	J:284566
	decreased hematopoietic stem cell number	J:284566
	decreased hemoglobin content	J:284566
	enlarged spleen	J:284566
	increased cellular sensitivity to ionizing radiation	J:284566
	increased erythroblast number	J:284566
	microphthalmia	J:284566
	postnatal growth retardation	J:284566
	postnatal lethality, incomplete penetrance	J:284566
	prenatal lethality, incomplete penetrance	J:284566
	small ovary	J:284566
	small testis	J:284566
	weakness	J:284566
Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex} involves: 129S5/SvEvBrd	abnormal bone marrow cell morphology/development	J:285384
	decreased hematopoietic stem cell number	J:285384
	increased cellular sensitivity to DNA damaging agents	J:285384
	thrombocytopenia	J:285384
Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex} involves: 129S5/SvEvBrd * C57BL/6	abnormal male meiosis	J:146616
	abnormal seminiferous tubule morphology	J:146616
	abnormal spermatocyte morphology	J:146616
	decreased body weight	J:146616
	decreased mature ovarian follicle number	J:146616
	fetal growth retardation	J:146616
	increased adenoma incidence	J:146616
	increased carcinoma incidence	J:146616
	microphthalmia	J:146616
	oligozoospermia	J:146616
	perinatal lethality, incomplete penetrance	J:146616
	postnatal growth retardation	J:146616
	small testis	J:146616
Fancd2^tm1Hou/Fancd2^tm1Hou 129S4/SvJae-Fancd2^tm1Hou	abnormal male meiosis	J:84892
	abnormal ovarian follicle number	J:84892
	abnormal seminiferous tubule morphology	J:84892
	abnormal spermatocyte morphology	J:84892
	increased adenoma incidence	J:84892
	increased carcinoma incidence	J:84892
	oligozoospermia	J:84892
	small testis	J:84892
Fancd2^tm1Hou/Fancd2^tm1Hou B6.129S4-Fancd2^tm1Hou	decreased body weight	J:84892
	fetal growth retardation	J:84892
	microphthalmia	J:84892
	perinatal lethality, incomplete penetrance	J:84892
	postnatal growth retardation	J:84892
Fancd2^tm1Hou/Fancd2^tm1Hou involves: 129S4/SvJae	decreased hematopoietic stem cell number	J:188123
	increased physiological sensitivity to xenobiotic	J:188123
	increased sensitivity to induced cell death	J:188123, J:193232
	infertility	J:193232
	normal mortality/aging	J:134461
Fancd2^tm1Hou/Fancd2^tm1Hou involves: 129S4/SvJae * C57BL/6J	increased adenoma incidence	J:84892
	increased carcinoma incidence	J:84892

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