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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kdm6b
KDM1 lysine (K)-specific demethylase 6B
MGI:2448492
51 phenotypes from 9 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal nervous system physiology J:196346
abnormal pre-Botzinger complex morphology J:196346
abnormal pre-Botzinger complex physiology J:196346
normal cardiovascular system phenotype J:196346
cyanosis J:196346
neonatal lethality, complete penetrance J:196346
normal respiratory system phenotype J:196346
Kdm6bGt(XB814)Byg/Kdm6bGt(XB814)Byg
Tg(Kdm6b*H1388A)21Gtes/0
involves: 129P2/OlaHsd * C57BL/6 		postnatal lethality, complete penetrance J:196346
Kdm6btm1.1Cdcn/Kdm6btm1.1Cdcn
involves: C57BL/6 		abnormal appendicular skeleton morphology J:233350
abnormal axial skeleton morphology J:233350
abnormal cartilage development J:233350
abnormal lung development J:233350
abnormal osteoblast differentiation J:233350
abnormal skeleton development J:233350
cyanosis J:233350
decreased bone mineralization J:233350
decreased bone ossification J:233350
decreased chondrocyte proliferation J:233350
decreased fetal size J:233350
decreased fetal weight J:233350
decreased length of long bones J:233350
decreased width of hypertrophic chondrocyte zone J:233350
delayed chondrocyte differentiation J:233350
delayed endochondral bone ossification J:233350
kyphosis J:233350
neonatal lethality, complete penetrance J:233350
short humerus J:233350
short limbs J:233350
Kdm6btm1.1Iwam/Kdm6btm1.2Iwam
Tg(Stra8-icre)1Reb/0
involves: 129P2/OlaHsd * C57BL/6J * FVB/NJ 		abnormal spermatogonia morphology J:206350
delayed reproductive senescence J:206350
enhanced male fertility J:206350
enlarged testis J:206350
Kdm6btm1.1Rbo/Kdm6btm1.1Rbo
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJae * C57BL/6J * CBA/J 		abnormal cell physiology J:323190
abnormal palatal mesenchymal cell differentiation J:323190
abnormal palatal mesenchymal cell proliferation J:323190
abnormal palate development J:323190
abnormal soft palate morphology J:323190
abnormal soft palate muscle morphology J:323190
complete cleft palate J:323190
flat head J:323190
maxillary shelf hypoplasia J:323190
neonatal lethality, complete penetrance J:323190
palatal shelf hypoplasia J:323190
palatine bone horizontal plate hypoplasia J:323190
Kdm6btm1.1Rbo/Kdm6btm1.1Rbo
Tg(KRT14-cre)1Amc/0
involves: 129S4/SvJae * C57BL/6J * C57BL/6N * CBA 		normal craniofacial phenotype J:323190
Kdm6btm1.1Rfw/Kdm6btm1.1Rfw
Not Specified 		abnormal respiratory system physiology J:228713
increased cell proliferation J:228713
neonatal lethality J:228713
Kdm6btm1Aki/Kdm6btm1Aki
involves: 129X1/SvJ * C57BL/6 		abnormal lung morphology J:164690
abnormal response to infection J:164690
impaired eosinophil recruitment J:164690
perinatal lethality J:164690
thick pulmonary interalveolar septum J:164690
Kdm6btm1Iwam/Kdm6btm1Iwam
involves: 129P2/OlaHsd * C57BL/6J 		postnatal lethality J:206350
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory