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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chd2
chromodomain helicase DNA binding protein 2
MGI:2448567
84 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chd2em1Wei/Chd2em1Wei
involves: BALB/c * C57BL/6 		decreased body weight J:281371
prenatal lethality, incomplete penetrance J:281371
Chd2Gt(RRBO46)Byg/Chd2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood vessel morphology J:146176
abnormal kidney morphology J:146176
abnormal liver morphology J:146743
abnormal lung morphology J:146743
abnormal respiratory system physiology J:146743
abnormal spleen morphology J:146743
arteritis J:146176
bile duct hyperplasia J:146743
cardiac fibrosis J:146743
cardiomyopathy J:146743
cortical renal glomerulopathies J:146743
decreased birth body size J:146176
decreased body size J:146176
decreased body weight J:146743
decreased lymphocyte cell number J:146176
decreased survivor rate J:146176, J:146743
decreased white adipose tissue amount J:146743
disheveled coat J:146743
enlarged heart J:146743
enlarged lymph nodes J:146743
enlarged spleen J:146743
extramedullary hematopoiesis J:146176, J:146743
heart inflammation J:146176
hemorrhage J:146176
hepatic necrosis J:146743
increased CD4-positive, alpha-beta T cell number J:146176
increased lymphoma incidence J:146176
increased spleen red pulp amount J:146743
increased T cell derived lymphoma incidence J:146176
interstitial pneumonia J:146743
kyphosis J:146176, J:146743
lethargy J:146743
lipidosis J:146743
liver inflammation J:146743
lordosis J:146176
lymphoid hyperplasia J:146176
myocardial fiber degeneration J:146743
myocarditis J:146743
pale kidney J:146743
postnatal growth retardation J:146743
postnatal lethality, incomplete penetrance J:146176, J:146743
premature death J:146176, J:146743
pulmonary alveolar edema J:146743
pulmonary alveolar hemorrhage J:146743
tachypnea J:146743
weight loss J:146176
Chd2Gt(RRBO46)Byg/Chd2+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal blood vessel morphology J:137079
absent subcutaneous adipose tissue J:137079
cortical renal glomerulopathies J:137079
decreased body size J:137079
decreased subcutaneous adipose tissue amount J:137079
endometrium hyperplasia J:137079
increased heart atrium size J:137079
lordokyphosis J:137079
postnatal growth retardation J:137079
preweaning lethality, incomplete penetrance J:137079
uterus cyst J:137079
Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood cell morphology/development J:146176
abnormal blood vessel morphology J:146176
abnormal cell cycle J:146176
abnormal DNA repair J:146176
abnormal erythropoiesis J:146176
decreased erythroid progenitor cell number J:146176
decreased fetal size J:146743
fetal growth retardation J:146743
hemorrhage J:146176
increased cellular sensitivity to methylmethanesulfonate J:146176
increased cellular sensitivity to ultraviolet irradiation J:146176
increased cellular sensitivity to X-ray irradiation J:146176
increased megakaryocyte cell number J:146176
lethargy J:146176
postnatal lethality J:146176
postnatal lethality, complete penetrance J:146743
Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
involves: 129P2/OlaHsd * C57BL/6J 		abnormal eye morphology J:137079
anophthalmia J:137079
decreased body size J:137079
increased heart atrium size J:137079
lethality throughout fetal growth and development, incomplete penetrance J:137079
pallor J:137079
postnatal lethality, complete penetrance J:137079
Chd2tm1b(EUCOMM)Hmgu/Chd2tm1b(EUCOMM)Hmgu
C57BL/6N-Chd2tm1b(EUCOMM)Hmgu/Tcp 		abnormal bone structure J:211773
abnormal sinus arrhythmia J:211773
decreased body length J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased erythrocyte cell number J:211773
decreased hemoglobin content J:211773
decreased mean platelet volume J:211773
decreased prepulse inhibition J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
increased grip strength J:211773
short tibia J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory