Gars1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gars1
glycyl-tRNA synthetase 1
MGI:2449057

50 phenotypes from 6 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gars1^C201R/Gars1⁺ involves: BALB/cAnN * C3H/HeH	abnormal sciatic nerve morphology	J:149830
	decreased grip strength	J:149830
	decreased locomotor activity	J:149830
	impaired coordination	J:149830
	impaired fine motor coordination	J:149830
	normal nervous system phenotype	J:149830
Gars1^C201R/Gars1⁺ involves: BALB/cAnN * C3H/HeH * C57BL/6J	abnormal innervation pattern to muscle	J:149830
	abnormal neuromuscular synapse morphology	J:149830, J:179811
	abnormal sensory neuron morphology	J:149830
	abnormal tibialis anterior morphology	J:149830
	decreased body weight	J:149830
	decreased grip strength	J:149830, J:179811
	decreased nerve conduction velocity	J:149830, J:179811
	decreased skeletal muscle fiber number	J:149830
	decreased tibialis anterior weight	J:149830
	muscle weakness	J:149830
	normal nervous system phenotype	J:179811
Gars1^C201R/Gars1⁺ Tg(Thy1-YFP)16Jrs/? involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA	abnormal neuromuscular synapse morphology	J:229590
	abnormal PNS synaptic transmission	J:229590
	abnormal synaptic transmission	J:229590
	decreased grip strength	J:229590
Gars1^C201R/Gars1^C201R involves: BALB/cAnN * C3H/HeH	abnormal locomotor activation	J:149830
	decreased body weight	J:149830
	impaired limb coordination	J:149830
	postnatal lethality, complete penetrance	J:149830
	prenatal lethality, incomplete penetrance	J:149830
Gars1^C201R/Gars1^C201R involves: BALB/cAnN * C3H/HeH * C57BL/6J	postnatal lethality, complete penetrance	J:149830, J:179811
	prenatal lethality, incomplete penetrance	J:149830, J:179811
Gars1^C201R/Gars1^Nmf249 involves: BALB/cAnN * C3H/HeH * C57BL/6J	abnormal axon morphology	J:179811
	abnormal neuromuscular synapse morphology	J:179811
	decreased body weight	J:179811
	normal mortality/aging	J:179811
Gars1^em1(IMPC)Tcp/Gars1⁺ C57BL/6NCrl-Gars1^em1(IMPC)Tcp/Tcp	abnormal eye morphology	J:211773
	abnormal seminal vesicle morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal sternum morphology	J:211773
	abnormal stomach morphology	J:211773
	decreased exploration in new environment	J:211773
	enlarged heart	J:211773
	enlarged urinary bladder	J:211773
	increased circulating triglyceride level	J:211773
	small spleen	J:211773
Gars1^em1(IMPC)Tcp/Gars1^em1(IMPC)Tcp C57BL/6NCrl-Gars1^em1(IMPC)Tcp/Tcp	embryonic lethality prior to organogenesis	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
Gars1^em1Rwb/Gars1^em2Rwb involves: C57BL/6NJ * FVB/NJ	abnormal axon morphology	J:284948
	abnormal neuromuscular synapse morphology	J:284948
	axon degeneration	J:284948
	decreased body weight	J:284948
	decreased grip strength	J:284948
	decreased nerve conduction velocity	J:284948
	muscular atrophy	J:284948
Gars1^{Gt(XM256)6Byg}/Gars1⁺ involves: 129P2/OlaHsd * C57BL/6J	no abnormal phenotype detected	J:112221
Gars1^{Gt(XM256)6Byg}/Gars1^C201R involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J	prenatal lethality	J:179811
Gars1^{Gt(XM256)6Byg}/Gars1^{Gt(XM256)6Byg} involves: 129P2/OlaHsd * C57BL/6J	prenatal lethality, complete penetrance	J:112221
Gars1^{Gt(XM256)6Byg}/Gars1^Nmf249 involves: 129P2/OlaHsd * C57BL/6J	prenatal lethality, complete penetrance	J:112221
Gars1^Nmf249/Gars1⁺ C57BL/6J-Gars1^Nmf249/J	abnormal axon morphology	J:82238, J:112221
	abnormal gait	J:82238
	abnormal innervation pattern to muscle	J:82238
	abnormal nerve conduction	J:112221
	abnormal neuromuscular synapse morphology	J:112221
	abnormal PNS synaptic transmission	J:112221
	axon degeneration	J:112221
	decreased body size	J:82238
	decreased muscle weight	J:112221
	muscular atrophy	J:112221
	normal nervous system phenotype	J:82238
	postnatal growth retardation	J:82238
	premature death	J:82238, J:112221
Gars1^Nmf249/Gars1⁺ involves: C57BL/6J * CAST/Ei	abnormal axon morphology	J:179811
	abnormal nervous system morphology	J:179811
	abnormal neuromuscular synapse morphology	J:179811
	decreased body weight	J:179811
	decreased nerve conduction velocity	J:179811
	demyelination	J:179811
Gars1^Nmf249/Gars1⁺ Tg(Thy1-YFP)16Jrs/? involves: C57BL/6J * CAST/Ei * CBA/J	abnormal endplate potential	J:229590
	abnormal neuromuscular synapse morphology	J:229590
	abnormal PNS synaptic transmission	J:229590
	abnormal synaptic transmission	J:229590
	decreased grip strength	J:229590
Gars1^Nmf249/Gars1^Nmf249 C57BL/6J-Gars1^Nmf249/J	prenatal lethality, complete penetrance	J:112221

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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